Skonieczna Magdalena, Hejmo Tomasz, Poterala-Hejmo Aleksandra, Cieslar-Pobuda Artur, Buldak Rafal J
Institute of Automatic Control, Silesian University of Technology, Akademicka 16, 44-100 Gliwice, Poland.
Biotechnology Centre, Silesian University of Technology, Krzywoustego 8, 44-100 Gliwice, Poland.
Oxid Med Cell Longev. 2017;2017:9420539. doi: 10.1155/2017/9420539. Epub 2017 May 23.
NADPH oxidases (NOX) are reactive oxygen species- (ROS-) generating enzymes regulating numerous redox-dependent signaling pathways. NOX are important regulators of cell differentiation, growth, and proliferation and of mechanisms, important for a wide range of processes from embryonic development, through tissue regeneration to the development and spread of cancer. In this review, we discuss the roles of NOX and NOX-derived ROS in the functioning of stem cells and cancer stem cells and in selected aspects of cancer cell physiology. Understanding the functions and complex activities of NOX is important for the application of stem cells in tissue engineering, regenerative medicine, and development of new therapies toward invasive forms of cancers.
NADPH氧化酶（NOX）是产生活性氧（ROS）的酶，可调节众多依赖氧化还原的信号通路。NOX是细胞分化、生长和增殖的重要调节因子，对于从胚胎发育到组织再生，再到癌症发展和扩散等广泛过程的机制都很重要。在本综述中，我们讨论了NOX和NOX衍生的ROS在干细胞和癌症干细胞功能以及癌细胞生理学特定方面的作用。了解NOX的功能和复杂活性对于干细胞在组织工程、再生医学以及针对侵袭性癌症新疗法开发中的应用至关重要。
