Inhibitors of Adaptor-Associated Kinase 1 (AAK1) May Treat Neuropathic Pain, Schizophrenia, Parkinson's Disease, and Other Disorders.
作者信息
Abdel-Magid Ahmed F
机构信息
Therachem Research Medilab (India) Pvt. Ltd., Jaipur, India.
出版信息
ACS Med Chem Lett. 2017 May 26;8(6):595-597. doi: 10.1021/acsmedchemlett.7b00208. eCollection 2017 Jun 8.
Abstract
摘要
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本文引用的文献
1
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.抑制AAK1激酶作为治疗神经性疼痛的一种新型治疗方法。
J Pharmacol Exp Ther. 2016 Sep;358(3):371-86. doi: 10.1124/jpet.116.235333. Epub 2016 Jul 13.
2
Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage.抑制网格蛋白介导的内吞作用可预防淀粉样β蛋白诱导的轴突损伤。
Neurobiol Aging. 2015 May;36(5):1808-19. doi: 10.1016/j.neurobiolaging.2015.02.005. Epub 2015 Feb 13.
3
AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.使用整合化学基因组学和蛋白质组学，AAK1被鉴定为神经调节蛋白-1/ErbB4依赖性神经营养因子信号传导的抑制剂。
Chem Biol. 2011 Jul 29;18(7):891-906. doi: 10.1016/j.chembiol.2011.03.017.
4
The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton.Ark1/Prk1蛋白激酶家族。内吞作用和肌动蛋白骨架的调节因子。
EMBO Rep. 2003 Mar;4(3):246-51. doi: 10.1038/sj.embor.embor776.
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