High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China.
Science Island Branch of Graduate School, University of Science and Technology of China, Hefei 230026, China.
Int J Mol Sci. 2019 Apr 10;20(7):1760. doi: 10.3390/ijms20071760.
STK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among all eukaryotes. STK16 is distantly related to the other kinases and belongs to the NAK kinase family that has an atypical activation loop architecture. As a membrane-associated protein that is primarily localized to the Golgi, STK16 has been shown to participate in the TGF-β signaling pathway, TGN protein secretion and sorting, as well as cell cycle and Golgi assembly regulation. This review aims to provide a comprehensive summary of the progress made in recent research about STK16, ranging from its distribution, molecular characterization, post-translational modification (fatty acylation and phosphorylation), interactors (GlcNAcK/DRG1/MAL2/Actin/WDR1), and related functions. As a relatively underexplored kinase, more studies are encouraged to unravel its regulation mechanisms and cellular functions.
STK16（丝氨酸/苏氨酸激酶 16，也称为 Krct/PKL12/MPSK1/TSF-1）是一种豆蔻酰化和棕榈酰化的丝氨酸/苏氨酸蛋白激酶，在所有真核生物中广泛表达且保守。STK16 与其他激酶关系较远，属于 NAK 激酶家族，其具有非典型的激活环结构。作为一种主要定位于高尔基体的膜相关蛋白，STK16 已被证明参与 TGF-β信号通路、TGN 蛋白分泌和分拣以及细胞周期和高尔基体组装的调节。本综述旨在全面总结 STK16 的最新研究进展，包括其分布、分子特征、翻译后修饰（脂肪酸酰化和磷酸化）、相互作用蛋白（GlcNAcK/DRG1/MAL2/Actin/WDR1）以及相关功能。作为一种相对未被充分研究的激酶，鼓励开展更多研究以揭示其调控机制和细胞功能。
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