Department of Cardiology, Tianjin Medical University General Hospital, Tianjin Medical University, No. 154, Anshan Road, Heping District, Tianjin 300052, China.
Biomed Res Int. 2017;2017:7657306. doi: 10.1155/2017/7657306. Epub 2017 May 24.
Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable. In the present research, to gain insight into candidate biomarkers, the author draws on H NMR-based serum metabolic profiling to analyze the unstable angina pectoris (UAP) metabolic signatures; this constitutes an effective way to produce medical diagnosis. 101 unstable angina pectoris patients and 132 healthy controls were enrolled and 22 serum samples from each group were analyzed. Effective separation was noted regarding the UAP and control groups, and, for the former group considered in relation to their counterpart, the serum concentrations of Lac, m-I, lipid, VLDL, 3-HB, and LDL were higher whereas the concentrations of Thr, Cr, Cho, PC/GPC, Glu, Gln, Lys, HDL, Ile, Leu, and Val were lower. The conclusion drawn in view of the results is that the plasma metabolomics examined by H NMR displayed promise for biomarker identification for UA. In addition to this, the analysis illuminated the metabolic processes of UA.
尽管不稳定型心绞痛（UA）是一种具有全球高死亡率和发病率的冠心病（CHD）形式，其危险性的统计证据已经很明确，但需要认识到，该病症的诊断精度并不理想。在本研究中，为了深入了解候选生物标志物，作者利用基于 H NMR 的血清代谢组学分析不稳定型心绞痛（UAP）的代谢特征；这是一种有效的医学诊断方法。共纳入 101 例不稳定型心绞痛患者和 132 例健康对照者，并对每组的 22 份血清样本进行了分析。UAP 组和对照组之间的分离效果显著，与对照组相比，前者的血清 Lac、m-I、脂质、VLDL、3-HB 和 LDL 浓度较高，而 Thr、Cr、Cho、PC/GPC、Glu、Gln、Lys、HDL、Ile、Leu 和 Val 浓度较低。鉴于这些结果，可以得出结论，H NMR 检测的血浆代谢组学在 UA 的生物标志物识别方面具有潜力。此外，该分析还阐明了 UA 的代谢过程。
