Auerbach Randy P, Tarlow Naomi, Bondy Erin, Stewart Jeremy G, Aguirre Blaise, Kaplan Cynthia, Yang Wenhui, Pizzagalli Diego A
Department of Psychiatry (RPA, NT, EB, JGS, BA, CK, WY, DAP), McLean Hospital, Center for Depression, Anxiety and Stress Research, Harvard Medical School, Boston, Massachusetts; and Department of Psychology (WY), Hunan Normal University, Hunan, China.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jul;1(4):335-344. doi: 10.1016/j.bpsc.2016.04.004.
Borderline personality disorder (BPD) is debilitating, and theoretical models have postulated that cognitive-affective biases contribute to the onset and maintenance of BPD symptoms. Despite advances, our understanding of BPD pathophysiology in youth is limited. The present study used event-related potentials (ERPs) to identify cognitive-affective processes that underlie negative self-referential processing in BPD youth.
Healthy females ( = 33) and females with BPD ( = 26) 13 to 22 years of age completed a self-referential encoding task while 128-channel electroencephalography data were recorded to examine early (i.e., P1 and P2) and late (late positive potential [LPP]) ERP components. Whole-brain standardized low-resolution electromagnetic tomography explored intracortical sources underlying significant scalp ERP effects.
Compared to healthy females, participants with BPD endorsed, recalled, and recognized fewer positive and more negative words. Moreover, unlike the healthy group, females with BPD had faster reaction times to endorse negative versus positive words. In the scalp ERP analyses, the BPD group had greater P2 and late LPP positivity to negative as opposed to positive words. For P2 and late LPP, whole-brain standardized low-resolution electromagnetic tomography analyses suggested that females with BPD overrecruit frontolimbic circuitry in response to negative stimuli.
Collectively, these findings show that females with BPD process negative self-relevant information differently than healthy females. Clinical implications and future directions are discussed.
边缘型人格障碍（BPD）具有致残性，理论模型推测认知情感偏差会导致BPD症状的发生和维持。尽管取得了进展，但我们对青少年BPD病理生理学的理解仍然有限。本研究使用事件相关电位（ERP）来识别BPD青少年负性自我参照加工背后的认知情感过程。
13至22岁的健康女性（n = 33）和BPD女性（n = 26）完成一项自我参照编码任务，同时记录128通道脑电图数据，以检查早期（即P1和P2）和晚期（晚期正电位[LPP]）ERP成分。全脑标准化低分辨率电磁断层扫描探索了头皮ERP显著效应背后的皮质内来源。
与健康女性相比，BPD患者认可、回忆和识别的积极词汇较少，消极词汇较多。此外，与健康组不同，BPD女性对消极词汇与积极词汇的反应时间更快。在头皮ERP分析中，BPD组对消极词汇而非积极词汇的P2和晚期LPP正性更大。对于P2和晚期LPP，全脑标准化低分辨率电磁断层扫描分析表明，BPD女性在对消极刺激的反应中过度激活额边缘回路。
总体而言，这些发现表明，BPD女性与健康女性处理负性自我相关信息的方式不同。讨论了临床意义和未来方向。
