The Histogenesis of Ewing Sarcoma.
作者信息
Tu Jian, Huo Zijun, Gingold Julian, Zhao Ruiying, Shen Jingnan, Lee Dung-Fang
机构信息
Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
出版信息
Cancer Rep Rev. 2017;1(2). doi: 10.15761/CRR.1000111. Epub 2017 Feb 7.
Abstract
摘要
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本文引用的文献
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Efficient generation and reversion of chromosomal translocations using CRISPR/Cas technology.利用CRISPR/Cas技术高效产生和逆转染色体易位
BMC Genomics. 2016 Sep 17;17(1):739. doi: 10.1186/s12864-016-3084-5.
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Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.致癌融合蛋白EWS-FLI1是一个调控可变剪接的网络枢纽。
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EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma.EWS-FLI1利用不同的染色质重塑机制直接激活或抑制尤因肉瘤中的增强子元件。
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Engineering human tumour-associated chromosomal translocations with the RNA-guided CRISPR-Cas9 system.利用 RNA 引导的 CRISPR-Cas9 系统工程化人类肿瘤相关染色体易位。
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Modeling initiation of Ewing sarcoma in human neural crest cells.建立人神经嵴细胞尤文肉瘤的模型。
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EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells.EWS-FLI-1表达在原代人骨髓间充质干细胞中触发尤因肉瘤起始程序。
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A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature.一项转录谱荟萃分析揭示了核心EWS-FLI基因表达特征。
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Mesenchymal stem cell features of Ewing tumors.尤因肉瘤的间充质干细胞特征
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Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells.源自原发性骨髓间充质祖细胞的尤因肉瘤的发展。
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Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors.EWS/FLI-1致癌基因在小鼠原代骨源细胞中的表达导致了EWS/FLI-1依赖性的尤文肉瘤样肿瘤。
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