Magnusson I, Cho J W, Ihre T, Olsson J E, Posloncek B, Uvnäs-Moberg K, Ost A
Scand J Gastroenterol. 1985 Jun;20(5):623-8. doi: 10.3109/00365528509089707.
Five patients with megaloblastic anemia due to deficiency of vitamin B12 and achlorhydria and six normal controls participated in the study. The patients with pernicious anemia (PA) had elevated plasma gastrin levels, as expected, and lower plasma somatostatin (SST) levels than the control patients. The amount of gastrin and SST in the antral mucosa did not differ in the two groups of patients. In the fundic mucosa, the patients with PA had increased tissue concentrations of both gastrin and SST as compared with the tissue concentrations in the controls. These findings of hormone tissue concentrations were correlated to the number of argyrophilic cells. Thus, in the antral mucosa the number of argyrophilic cells did not differ in patients with PA and in the controls. In the fundic mucosa, however, the number of argyrophilic cells was significantly elevated in patients with PA as compared with the controls.
五名因维生素B12缺乏和胃酸缺乏导致巨幼细胞贫血的患者以及六名正常对照者参与了该研究。正如预期的那样，恶性贫血（PA）患者的血浆胃泌素水平升高，且血浆生长抑素（SST）水平低于对照患者。两组患者胃窦黏膜中胃泌素和SST的含量无差异。在胃底黏膜中，与对照组的组织浓度相比，PA患者的胃泌素和SST组织浓度均升高。这些激素组织浓度的发现与嗜银细胞数量相关。因此，在胃窦黏膜中，PA患者和对照者的嗜银细胞数量无差异。然而，在胃底黏膜中，与对照组相比，PA患者的嗜银细胞数量显著升高。
