Iglesia Iris, González-Gross Marcela, Huybrechts Inge, De Miguel-Etayo Pilar, Molnar Denes, Manios Yannis, Widhalm Kurt, Gottrand Frédéric, Kafatos Anthony, Marcos Asensión, De la O Puerta Alejandro, Leclercq Catherine, De Henauw Stefaan, Stehle Peter, Kersting Mathilde, Mouratidou Theodora, Moreno Luis Alberto
GENUD (Growth, Exercise, Nutrition and Development) Research group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza.
Nutr Hosp. 2017 Jun 5;34(3):568-577. doi: 10.20960/nh.559.
To assess whether adolescents with high body mass index (BMI), or fat mass index (FMI), in combination with insulin resistance (assessed with the Homeostatic Model Assessment [HOMA] index), had also lower blood vitamin B6, folate and vitamin B12 concentrations.
Six hundred and fifteen adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, with data on B-vitamins (both intakes and status), and BMI, FMI, HOMA, were selected. Intakes were assessed by two non-consecutive 24-h recalls. B-vitamins biomarkers were measured by chromatography and immunoassay. Analysis of covariance was applied to elucidate the differences in B-vitamins between combinations of groups defined according to the median of the z-scores of markers of body composition and insulin sensitivity.
When considering energy intakes and education of the mother in the model, in females, vitamin B6 intakes were higher in the high BMI/high HOMA group than in the high BMI-low HOMA group. Similarly, vitamin B6 intakes were higher in the high FMI/high HOMA group than in the low FMI/low HOMA group. Plasma vitamin B12 was significantly lower in males in the high FMI/high HOMA group than in the low FMI/low HOMA group, keeping also significant their trends throughout the groups, a fact that can be observed also for females (p < 0.05).
Adolescents with combined higher adiposity and higher HOMA insulin sensitivity showed lower vitamin B12 plasma concentrations. These differences do not seem to be explained by dietary vitamin B12 intake.
评估体重指数（BMI）或体脂指数（FMI）较高且伴有胰岛素抵抗（采用稳态模型评估[HOMA]指数进行评估）的青少年，其血液中维生素B6、叶酸和维生素B12浓度是否也较低。
从欧洲青少年营养健康生活方式（HELENA）研究中选取了615名青少年，他们有关于B族维生素（摄入量和状态）、BMI、FMI、HOMA的数据。摄入量通过两次非连续的24小时膳食回顾进行评估。B族维生素生物标志物通过色谱法和免疫测定法进行测量。应用协方差分析来阐明根据身体成分和胰岛素敏感性标志物的z分数中位数定义的各组组合之间B族维生素的差异。
在模型中考虑能量摄入量和母亲的教育程度时，在女性中，高BMI/高HOMA组的维生素B6摄入量高于高BMI/低HOMA组。同样，高FMI/高HOMA组的维生素B6摄入量高于低FMI/低HOMA组。高FMI/高HOMA组男性的血浆维生素B12显著低于低FMI/低HOMA组，并且在各组中其趋势也保持显著，女性也有此现象（p<0.05）。
肥胖程度较高且HOMA胰岛素敏感性较高的青少年血浆维生素B12浓度较低。这些差异似乎不能用膳食维生素B12摄入量来解释。
