González Jiménez David, Muñoz-Codoceo Rosana, Garriga-García María, Molina-Arias Manuel, Álvarez-Beltrán Marina, García-Romero Ruth, Martínez-Costa Cecilia, Meavilla-Olivas Silvia María, Peña-Quintana Luis Rodrigo, Gallego Gutiérrez Silvia, Marugán de Miguelsanz José Manuel, Suárez Cortina Lucrecia, Castejón Ponce Esperanza Natividad, Leis Trabazo Rosaura, Martín Cruz Fayna, Díaz Martín Juan José, Bousoño García Carlos
HOSPITAL CARMEN Y SEVERO OCHOA.
Nutr Hosp. 2017 Jun 5;34(3):578-583. doi: 10.20960/nh.620.
The primary objective of this study was to find out the prevalence of overweight and obese status, as well as their association to pulmonary function, total cholesterol and vitamin D in patients with cystic fibrosis (CF).
This is a multicenter descriptive and cross-sectional study. Twelve Spanish hospitals participated. 451 patients with CF were included. Adults were classified according to body mass index (BMI) and children were classified according to BMI percentiles (WHO tables). Pearson's correlation, Anova, Student's t-test and multiple linear regression were conducted.
Mean age was 12.3 (range 4-57) years old, 51% were male and 18% had pancreatic sufficiency. Participants were classified in five nutritional status categories: 12% were malnourished; 57%, at nutritional risk; 24%, normally nourished; 6%, overweight; and 1%, obese. Pulmonary function in overweight or obese patients (91 ± 19%) was better than in malnourished patients (77 ± 24%) (p = 0.017). However, no difference was observed between those at nutritional risk (86 ± 19%) or normally nourished (90 ± 22%) groups. Overweight and obese patients had higher levels of total cholesterol (p = 0.0049), a greater proportion of hypercholesterolemia (p = 0.001), as well as lower levels of 25 OH vitamin D (p = 0.058).
Prevalence of overweight and obese was 6 and 1%. Excess weight status does not offer any benefit in pulmonary function in comparison to normally nourished patients.
本研究的主要目的是查明囊性纤维化（CF）患者中超重和肥胖状态的患病率，以及它们与肺功能、总胆固醇和维生素D的关联。
这是一项多中心描述性横断面研究。十二家西班牙医院参与其中。纳入了451例CF患者。成人根据体重指数（BMI）分类，儿童根据BMI百分位数（世界卫生组织表格）分类。进行了Pearson相关性分析、方差分析、学生t检验和多元线性回归分析。
平均年龄为12.3岁（范围4 - 57岁），51%为男性，18%有胰腺功能不全。参与者被分为五个营养状况类别：12%营养不良；57%有营养风险；24%营养正常；6%超重；1%肥胖。超重或肥胖患者的肺功能（91±19%）优于营养不良患者（77±24%）（p = 0.017）。然而，有营养风险组（86±19%）或营养正常组（90±22%）之间未观察到差异。超重和肥胖患者的总胆固醇水平较高（p = 0.0049），高胆固醇血症比例更大（p = 0.001），以及25羟维生素D水平较低（p = 0.058）。
超重和肥胖的患病率分别为6%和1%。与营养正常的患者相比，超重状态对肺功能没有任何益处。
