Holden Emily C, Dodge Laura E, Sneeringer Rita, Moragianni Vasiliki A, Penzias Alan S, Hacker Michele R
a Department of Obstetrics and Gynecology , Beth Israel Deaconess Medical Center , Boston , MA , USA.
b Department of Obstetrics, Gynecology and Reproductive Biology , Harvard Medical School , Boston , MA , USA.
Hum Fertil (Camb). 2018 Dec;21(4):288-293. doi: 10.1080/14647273.2017.1334130. Epub 2017 Jun 18.
Our objective was to determine if a correlation exists between endometrial thickness measured on the day of ovulation trigger during an in vitro fertilization (IVF) cycle and pregnancy outcomes among non-cancelled cycles. We performed a retrospective cohort study looking at 6331 women undergoing their first, fresh autologous IVF cycle from 1 May 2004 to 31 December 2012 at Boston IVF (Waltham, MA). Our primary outcome was the risk ratio (RR) of live birth and positive β-hCG. We found that thicker endometrial linings were associated with positive β-hCG and live birth rates. For each additional millimetre of endometrial thickness, we found a statistically significant increased risk of positive β-hCG (adjusted RR: 1.14; 95% CI: 1.09-1.18) and live birth (RR: 1.08; 95% CI: 1.05-1.11). There was no association between endometrial thickness and miscarriage (RR: 0.99; 95% CI: 0.91-1.07). Similar results were seen when categorizing endometrial thickness. Compared with an endometrial thickness >7 to <11 mm, the likelihood of a live birth was significantly higher for an endometrial thickness ≥11 mm (adjusted RR: 1.23; 95% CI: 1.11-1.37) and significantly lower for the ≤7 mm group (adjusted RR: 0.64; 95% CI: 0.45-0.90). In conclusion, thicker endometrial linings were associated with increased pregnancy and live birth rates.
我们的目标是确定在体外受精（IVF）周期中触发排卵当天测量的子宫内膜厚度与未取消周期的妊娠结局之间是否存在相关性。我们进行了一项回顾性队列研究，观察了2004年5月1日至2012年12月31日在波士顿体外受精中心（马萨诸塞州沃尔瑟姆）接受首次新鲜自体IVF周期治疗的6331名女性。我们的主要结局是活产和β-hCG阳性的风险比（RR）。我们发现，较厚的子宫内膜与β-hCG阳性及活产率相关。子宫内膜厚度每增加1毫米，我们发现β-hCG阳性（校正RR：1.14；95%CI：1.09 - 1.18）和活产（RR：1.08；95%CI：1.05 - 1.11）的风险在统计学上显著增加。子宫内膜厚度与流产之间无关联（RR：0.99；95%CI：0.91 - 1.07）。对子宫内膜厚度进行分类时也观察到了类似结果。与子宫内膜厚度>7至<11毫米相比，子宫内膜厚度≥11毫米时活产的可能性显著更高（校正RR：1.23；95%CI：1.11 - 1.37），而≤7毫米组则显著更低（校正RR：0.64；95%CI：0.45 - 0.90）。总之，较厚的子宫内膜与妊娠率和活产率增加相关。
