Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.
Reprod Biol Endocrinol. 2010 Mar 24;8:30. doi: 10.1186/1477-7827-8-30.
To evaluate the combined effect of endometrial thickness and pattern on clinical outcome in patients undergoing in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET).
Cycles of IVF/ICSI-ET conducted between January 2003 and December 2008 at a university-based reproductive center were reviewed retrospectively. Endometrial ultrasonographic characteristics were recorded on the day of hCG administration. In the combined analysis, endometrial thickness groups (group 1: equal or <7 mm; group 2: 7-14 mm; group 3: >14 mm) were subdivided into two endometrial patterns (pattern A: triple-line; pattern B: no-triple line). Clinical pregnancy rate (CPR) and early miscarriage rate in different groups were analyzed.
A total of 2896 cycles were reviewed. Clinical pregnancy rate (CPR) was 24.4% in group 1-A. There were no second trimester pregnancies in group 1-B. Miscarriage rate in group 2-A was significantly lower compared to group 2-B (P < 0.01), although CPR did not show any significant differences between the groups. A no-triple line endometrial pattern with moderate endometrial thickness (7-14 mm) had a detrimental effect on pregnancy outcome, but not the occurrence of pregnancy. In group 3, there was no difference in CPR and miscarriage rates between the two patterns; adequate endometrial thickness (>14 mm) seemed to mitigate the detrimental impact (high miscarriage rate) of pattern B.
Combined analysis of endometrial thickness and pattern on the day of hCG administration was a better predictor of the outcome of IVF/ICSI-ET and may be more helpful for patient counseling than the separate analyses.
评估子宫内膜厚度和形态对体外受精/卵胞浆内单精子注射和胚胎移植（IVF/ICSI-ET）患者临床结局的联合影响。
回顾性分析 2003 年 1 月至 2008 年 12 月在一家大学生殖中心进行的 IVF/ICSI-ET 周期。在 hCG 给药日记录子宫内膜超声特征。在联合分析中，将子宫内膜厚度组（组 1：相等或<7mm；组 2：7-14mm；组 3：>14mm）细分为两种子宫内膜形态（A 型：三线；B 型：无三线）。分析不同组的临床妊娠率（CPR）和早期流产率。
共回顾了 2896 个周期。组 1-A 的 CPR 为 24.4%。组 1-B 中没有妊娠至中期。组 2-A 的流产率明显低于组 2-B（P<0.01），尽管两组的 CPR 没有显示出任何显著差异。具有中等子宫内膜厚度（7-14mm）的无三线子宫内膜形态对妊娠结局有不利影响，但不影响妊娠的发生。在组 3 中，两种形态的 CPR 和流产率没有差异；足够的子宫内膜厚度（>14mm）似乎减轻了 B 型的不利影响（高流产率）。
在 hCG 给药日对子宫内膜厚度和形态进行联合分析是预测 IVF/ICSI-ET 结局的更好指标，比单独分析可能更有助于患者咨询。
