Yan Li-Rong, Liu Ao-Ran, Jiang Li-Yue, Wang Ben-Gang
Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Key Laboratory of Cancer Etiology and Prevention, China Medical University, Liaoning Provincial Education Department, Shenyang, China.
Tangdu Hospital of the Fourth Military Medical University, Xi'an, China.
Front Med (Lausanne). 2022 Sep 20;9:995943. doi: 10.3389/fmed.2022.995943. eCollection 2022.
A bibliometric analysis for non-coding RNA and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) was performed to describe international research status and visualize the research scope and emerging trends over the last two decades on this topic.
Research data of non-coding RNA and HBV-related HCC were retrieved and extracted from the Web of Science Core Collection (WoSCC) database from 1 January 2003 to 13 June 2022 and then analyzed by means of bibliometric methods. A total of 1,036 articles published in this field were assessed for specific characteristics, including the year of publication, journal, author, institution, country/region, references, and keywords. VOSviewer was employed to perform co-authorship, co-occurrence, and co-citation analyses accompanied by constructing a visual network.
Overall, 1,036 reports on non-coding RNA and HBV-related HCC from 2003 to 2022 were retrieved from WoSCC. The publication has gradually increased during the last two decades with 324 journals involved. Most research records (748 publications and 23,184 citations) were concentrated in China. A co-occurrence cluster analysis for the top 100 keywords was performed and four clusters were generated: (1) non-coding RNA as a molecular marker for the diagnosis and prognosis of HBV-related HCC; (2) dysregulation of non-coding RNA by hepatitis B virus X protein (HBx); (3) non-coding RNA affecting the biological behaviors of HBV-related HCC; and (4) epidemiological study for the effects of non-coding RNA on the risk of HBV-related HCC.
The publications and citations involved in non-coding RNA and HBV-related HCC have increased over the last two decades associated with many countries, institutions, and authors. Our study revealed current development trends, global cooperation models, basic knowledge, research hotspots, and emerging frontiers in this field.
对非编码RNA与乙型肝炎病毒（HBV）相关肝细胞癌（HCC）进行文献计量分析，以描述国际研究现状，并可视化过去二十年该主题的研究范围和新趋势。
从2003年1月1日至2022年6月13日的Web of Science核心合集（WoSCC）数据库中检索并提取非编码RNA与HBV相关HCC的研究数据，然后采用文献计量方法进行分析。对该领域发表的1036篇文章评估其具体特征，包括发表年份、期刊、作者、机构、国家/地区、参考文献和关键词。使用VOSviewer进行合作作者、共现和共被引分析，并构建可视化网络。
总体而言，从WoSCC中检索到2003年至2022年关于非编码RNA与HBV相关HCC的1036份报告。在过去二十年中，发表量逐渐增加，涉及324种期刊。大多数研究记录（748篇出版物和23184次引用）集中在中国。对前100个关键词进行共现聚类分析，生成了四个聚类：（1）非编码RNA作为HBV相关HCC诊断和预后的分子标志物；（2）乙型肝炎病毒X蛋白（HBx）对非编码RNA的失调作用；（3）非编码RNA影响HBV相关HCC的生物学行为；（4）非编码RNA对HBV相关HCC风险影响的流行病学研究。
在过去二十年中，与非编码RNA和HBV相关HCC相关的出版物和引用量有所增加，涉及许多国家、机构和作者。我们的研究揭示了该领域当前的发展趋势、全球合作模式、基础知识、研究热点和新前沿。
