硫醇/二硫键稳态的临床应用
Clinical Utility of Thiol/Disulfide Homeostasis.
作者信息
Erenler Ali K, Yardan Turker
出版信息
Clin Lab. 2017 May 1;63(5):867-870. doi: 10.7754/Clin.Lab.2017.161117.
BACKGROUND
Recently, the usefulness of thiol/disulfide homeostasis (TDH) in various diseases is being widely investigated. In this mini-review, our aim is to clarify the role of TDH in clinical practice in the light of current literature.
METHODS
We performed a systematic review of the existing literature describing the clinical utility of TDH in the clinical setting. MEDLINE, EMBASE, and CINAHL were used as data sources. Two reviewers conducted independent screening and data extraction. Use of TDH in each system was investigated separately.
RESULTS
A total of 35 studies were detected in this mini-review. Our results revealed the protective role of TDH and its utility as a diagnostic marker in many common diseases in clinical practice.
CONCLUSIONS
Maintenance of TDH as a crucial part of antioxidant defense system is critical in diagnosis and prognosis of potentially lethal diseases.
背景
最近，硫醇/二硫化物稳态（TDH）在各种疾病中的作用正在被广泛研究。在本综述中，我们的目的是根据当前文献阐明TDH在临床实践中的作用。
方法
我们对描述TDH在临床环境中临床应用的现有文献进行了系统综述。使用MEDLINE、EMBASE和CINAHL作为数据源。两名审稿人进行独立筛选和数据提取。分别研究了TDH在每个系统中的应用。
结果
本综述共检索到35项研究。我们的结果揭示了TDH在临床实践中对许多常见疾病的保护作用及其作为诊断标志物的效用。
结论
维持TDH作为抗氧化防御系统的关键部分对潜在致命疾病的诊断和预后至关重要。
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