家族性高胆固醇血症患者的硫醇/二硫键平衡
Thiol/Disulfide Balance in Patients with Familial Hypercholesterolemia.
作者信息
Şimşek Özgür, Çarlıoğlu Ayşe, Alışık Murat, Edem Efe, Biçer Cemile Koca
机构信息
Internal Medicine Department, Erzurum Regional Education Research Hospital, Atatürk Mahallesi, Çat Yolu Cd., Palandöken, Yakutiye, Erzurum 25070, Turkey.
Biochemistry Department, Ankara Yıldırım Beyazıt University, Çankırı Caddesi, Çiçek Sokak No. 3, Ankara, Turkey.
出版信息
Cardiol Res Pract. 2018 Jun 12;2018:9042461. doi: 10.1155/2018/9042461. eCollection 2018.
OBJECTIVE
Herein, we investigated the balance of thiol/disulfide, with the hypothesis that the balance between disulfides and thiols, which are natural antioxidants, might be disrupted in patients with familial hypercholesterolemia, which eventually leads to endothelial damage.
METHODS
In this study, we evaluated 51 patients diagnosed with familial hypercholesterolemia and 81 healthy subjects. Blood samples were taken from the patients after a minimum of 12 hours of fasting; samples were immediately centrifuged, stored in Eppendorf tubes, and preserved at -80°C.
RESULTS
This study found that thiol levels are significantly lower in patients with familial hypercholesterolemia, whereas disulfide levels are higher (independent of age, gender, and body mass index). This means that in such patients, the thiol/disulfide balance changes in favour of disulfide.
CONCLUSIONS
In this study, we found that the thiol/disulfide balance in patients with familial hypercholesterolemia is disrupted in favour of disulfide.
目的
在此，我们研究了硫醇/二硫化物的平衡，基于这样的假设：作为天然抗氧化剂的二硫化物和硫醇之间的平衡，在家族性高胆固醇血症患者中可能会被打破，最终导致内皮损伤。
方法
在本研究中，我们评估了51名被诊断为家族性高胆固醇血症的患者和81名健康受试者。患者在至少禁食12小时后采集血样；样本立即离心，储存在艾本德管中，并保存在-80°C。
结果
本研究发现，家族性高胆固醇血症患者的硫醇水平显著降低，而二硫化物水平较高（与年龄、性别和体重指数无关）。这意味着在这类患者中，硫醇/二硫化物平衡向有利于二硫化物的方向变化。
结论
在本研究中，我们发现家族性高胆固醇血症患者的硫醇/二硫化物平衡被打破，有利于二硫化物。
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