Liu Raymond, Chan David C
Division of Biology and Biological Engineering, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA.
Nat Cell Biol. 2017 Jul;19(7):760-762. doi: 10.1038/ncb3565. Epub 2017 Jun 19.
Fusion between the inner membranes of two mitochondria requires the GTPase optic atrophy 1 (OPA1), but the molecular mechanism is poorly understood. A study now shows that fusion of two liposomes can be performed by OPA1 tethered to just one liposome, through an interaction with the phospholipid cardiolipin on the opposing liposome.
两个线粒体的内膜融合需要GTP酶视神经萎缩蛋白1（OPA1），但其分子机制仍知之甚少。一项研究表明，通过与相对脂质体上的磷脂心磷脂相互作用，仅连接到一个脂质体上的OPA1就能实现两个脂质体的融合。
