Ciurzyński Michał, Kurzyna Marcin, Kopeć Grzegorz, Błaszczak Piotr, Chrzanowski Łukasz, Kamiński Karol, Mizia-Stec Katarzyna, Mularek-Kubzdela Tatiana, Mroczek Ewa, Biederman Andrzej, Pruszczyk Piotr, Torbicki Adam
Klinika Chorób Wewnętrznych i Kardiologii z Centrum Diagnostyki i Leczenia Żylnej Choroby Zakrzepowo Zatorowej, Warszawski Uniwersytet Medyczny, Warszawa, Polska.
Kardiol Pol. 2017;75(6):620-627. doi: 10.5603/KP.2017.0110.
Both pharmacological and invasive treatment of chronic thromboembolic pulmonary hypertension (CTEPH) is now available in Poland and the awareness of the disease among physicians is growing. Thus, the Polish Cardiac Society's Working Group on Pulmonary Circulation in cooperation with independent experts in this field, have launched the statement on algorithm to guide a CTEPH diagnosis in patients with previous acute pulmonary embolism (APE). In Poland, every year this disease affects about 250 patients. CTEPH should be suspected in individuals after APE with dyspnea, despite at least 3 months period of effective anticoagulation, particularly when specified risk factors are present. Echocardiography is a main screening tool. The authors suggest that a diagnostic process of patients with significant clinical suspicion of CTEPH and right ventricle overload in echocardiography should be performed in reference centres. The document contains a list of Polish centres diagnosing patients with suspected CTEPH. Pulmonary scintigraphy is a safe and highly sensitive screening test for CTEPH. Multi-detector computed tomography with precise detection of thromboembolic residues in pulmonary circulation is important for planning of pulmonary endarterectomy. Right heart catheterisation definitely confirms the presence of pulmonary hypertension and direct pulmonary angiography allows for identification of lesions suitable for thromboendarterectomy or pulmonary balloon angioplasty. In this document a diagnostic algorithm in patients with suspected CTEPH is also proposed. With individualised sequential diagnostic strategy each patient can be finally qualified for a particular mode of therapy by dedicated CTEPH Heart Team. Moreover the document contains short information for the primary care physician about the management of patients after APE.
在波兰,慢性血栓栓塞性肺动脉高压(CTEPH)的药物治疗和侵入性治疗现已可用,医生对该疾病的认识也在不断提高。因此,波兰心脏病学会肺循环工作组与该领域的独立专家合作,发布了关于指导既往有急性肺栓塞(APE)患者进行CTEPH诊断的算法声明。在波兰,每年约有250名患者受此疾病影响。对于APE后出现呼吸困难的个体,即使经过至少3个月的有效抗凝治疗,尤其是存在特定危险因素时,也应怀疑CTEPH。超声心动图是主要的筛查工具。作者建议,对于临床高度怀疑CTEPH且超声心动图显示右心室负荷过重的患者,诊断过程应在参考中心进行。该文件包含波兰诊断疑似CTEPH患者的中心名单。肺闪烁扫描是CTEPH的一种安全且高度敏感的筛查试验。多排计算机断层扫描精确检测肺循环中的血栓栓塞残留对于肺内膜剥脱术的规划很重要。右心导管检查可明确证实肺动脉高压的存在,直接肺动脉造影可识别适合血栓内膜切除术或肺动脉球囊血管成形术的病变。本文还提出了疑似CTEPH患者的诊断算法。通过个体化的序贯诊断策略,每个患者最终都可由专业的CTEPH心脏团队确定适合的治疗模式。此外,该文件还为初级保健医生提供了关于APE后患者管理的简短信息。