细菌病原体对上皮细胞极性的调节。
Modulation of epithelial cell polarity by bacterial pathogens.
作者信息
Tapia Rocio, Kralicek Sarah E, Hecht Gail A
机构信息
Division of Gastroenterology and Nutrition, Department of Medicine, Loyola University Chicago, Maywood, Illinois.
Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois.
出版信息
Ann N Y Acad Sci. 2017 Oct;1405(1):16-24. doi: 10.1111/nyas.13388. Epub 2017 Jun 19.
Abstract
Epithelial cells constitute a physical barrier that aids in protecting the host from microbial pathogens. Polarized epithelial cells contain distinct apical and basolateral membrane domains separated by intercellular junctions, including tight junctions (TJs), which contribute to the maintenance of apical-basal polarity. Polarity complexes also contribute to the establishment of TJ formation. Several pathogens perturb epithelial TJ barrier function and structure in addition to causing a loss of apical-basal polarity. Here, we review the impact of pathogenic bacteria on the disruption of cell-cell junctions and epithelial polarity.
摘要
上皮细胞构成了一道物理屏障，有助于保护宿主免受微生物病原体的侵害。极化的上皮细胞包含由细胞间连接分隔的不同的顶端和基底外侧膜结构域，包括紧密连接（TJs），其有助于维持顶端 - 基底极性。极性复合物也有助于紧密连接的形成。除了导致顶端 - 基底极性丧失外，几种病原体还会扰乱上皮紧密连接屏障的功能和结构。在这里，我们综述了病原菌对细胞间连接破坏和上皮极性的影响。
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