El-Serafi Ahmed T, El-Serafi Ibrahim T, Elmasry Moustafa, Steinvall Ingrid, Sjöberg Folke
Sharjah Institute for Medical Research and College of Medicine, University of Sharjah, M27-138, P.O. Box 27272, Sharjah, UAE; Faculty of Medicine, Suez Canal University, Egypt.
Division of Experimental Cancer Medicine, Department of Laboratory Medicine, Karolinska Institutet, Sweden and Faculty of Medicine, Port-Said University, Egypt; The Burns Centre, Department of Hand Surgery and Plastic Surgery and Burns, Department of Clinical and Experimental Medicine, Linköping University, Sweden.
Differentiation. 2017 Jul-Aug;96:26-29. doi: 10.1016/j.diff.2017.06.002. Epub 2017 Jun 15.
Skin regeneration is a life-saving need for many patients, whom list is stretched from burn victims to motor-car accidents. Spraying cells, either keratinocytes or stem cells, were associated with variable results and, in many cases, unfavorable outcomes. As the spatial configuration of the skin is distinctive, many trials investigated the bio-printing or the construction of three dimensional skin models where different layers of the skin were preserved. Although some of these models showed the histological configuration of the skin, their acceptance by the wound was questionable as a consequence of delayed vascularization. In this mini-review, different models for three dimensional regeneration of the skin will be discussed with their main points of strength and challenges as well as their possible opportunities.
皮肤再生是许多患者的救命需求，这些患者包括烧伤受害者到车祸受害者等。喷洒细胞，无论是角质形成细胞还是干细胞，其结果各不相同，而且在许多情况下，效果并不理想。由于皮肤的空间结构独特，许多试验研究了生物打印或构建保留皮肤不同层的三维皮肤模型。尽管其中一些模型显示出皮肤的组织学结构，但由于血管化延迟，伤口对它们的接受程度值得怀疑。在这篇小型综述中，将讨论不同的皮肤三维再生模型，包括它们的主要优势、挑战以及可能的机会。
