You Renchuan, Zhang Jie, Gu Shaojin, Zhou Yingshan, Li Xiufang, Ye Dezhan, Xu Weilin
State Key Laboratory Cultivation Base for New Textile Materials & Advanced Processing Technology, College of Textile Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430200, China.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:430-435. doi: 10.1016/j.msec.2017.05.063. Epub 2017 May 12.
Protein-based composites have always been desirable biomaterials as they can be fabricated into a wide range of biomaterials with tunable properties, including modulation of mechanical properties and control of cell responses. Both egg white protein (EW) and silk fibroin (SF) are biocompatible, biodegradable, non-toxic and naturally abundant biopolymers. In order to obtain biocompatible composite films with tunable performance, EW and SF were blended at various ratios. Raising the SF ratio in the composite films significantly increased breaking strength, but impaired flexibility. Conversely, increasing the EW ratio remarkably enhanced elasticity of the composite films. Furthermore, the biological assays based on endothelial cells showed that the incorporation of EW promoted cell viability. These make them potential materials with controllable mechanical property and enhanced bioactivity, providing useful options for the fabrication of tissue engineering scaffolds.
基于蛋白质的复合材料一直是理想的生物材料，因为它们可以被制成具有可调性能的多种生物材料，包括机械性能的调节和细胞反应的控制。蛋清蛋白（EW）和丝素蛋白（SF）都是生物相容、可生物降解、无毒且天然丰富的生物聚合物。为了获得具有可调性能的生物相容性复合膜，将EW和SF以不同比例混合。提高复合膜中SF的比例显著提高了断裂强度，但损害了柔韧性。相反，增加EW的比例显著增强了复合膜的弹性。此外，基于内皮细胞的生物学测定表明，EW的加入促进了细胞活力。这些使它们成为具有可控机械性能和增强生物活性的潜在材料，为组织工程支架的制造提供了有用的选择。
