Toorell Hanna, Zetterberg Henrik, Blennow Kaj, Sävman Karin, Hagberg Henrik
a Perinatal Center, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska University Hospital , Gothenburg , Sweden.
b Clinical Neurochemistry Laboratory , Mölndal , Sweden.
J Matern Fetal Neonatal Med. 2018 Sep;31(18):2468-2472. doi: 10.1080/14767058.2017.1344964. Epub 2017 Jul 9.
Compare the levels of the brain injury biomarkers Tau and neurofilament light protein (NFL) in cases of asphyxia with those in controls.
We analyzed the neuronal proteins Tau and NFL in umbilical blood of 10 cases of severe-moderate intrapartum asphyxia and in 18 control cases.
The levels of both Tau and neurofilament were significantly higher after asphyxia and it appeared to be a correlation between the levels of the biomarkers and the severity of the insult.
Future studies are warranted to support or refute the value of Tau/NFLin clinical practice.
Fetal asphyxia remains a clinical problem resulting in life-long neurological disabilities. We urgently need more accurate early predictive markers to direct the clinician when to provide neuroprotective therapy.
比较窒息病例与对照组中脑损伤生物标志物Tau和神经丝轻链蛋白（NFL）的水平。
我们分析了10例重度至中度产时窒息病例和18例对照病例脐带血中的神经元蛋白Tau和NFL。
窒息后Tau和神经丝的水平均显著升高，且生物标志物水平与损伤严重程度之间似乎存在相关性。
有必要进行进一步研究以支持或反驳Tau/NFL在临床实践中的价值。
胎儿窒息仍然是一个导致终身神经残疾的临床问题。我们迫切需要更准确的早期预测标志物，以指导临床医生何时提供神经保护治疗。
