Costescu Strachinaru D I, Chaumont M, Gobin D, Sattar L, Strachinaru M, Karakike E, Roman A, Konopnicki D
a Infectious Diseases , Erasme University Hospital , Brussels , Belgium.
b Cardiology , Saint Pierre University Hospital , Brussels , Belgium.
Acta Clin Belg. 2018 Jun;73(3):220-223. doi: 10.1080/17843286.2017.1341691. Epub 2017 Jun 19.
Hemophagocytic lymphohistiocytosis (HLH) is a rare but severe and potentially fatal syndrome that is characterized by increased proliferation and activation of benign macrophages with hemophagocytosis throughout the reticuloendothelial system. This syndrome is classified as primary (genetic) or secondary when acquired in the context of infections (usually viral), malignancies, rheumatologic and metabolic diseases.
We report a case of HLH complicating a Haemophilus parainfluenzae mitral valve endocarditis and resolving under antibiotic and surgical treatment alone. We also review other case reports of infective endocarditis associated with HLH.
The syndrome is probably underdiagnosed. To our knowledge, this is the first report of a HLH syndrome associated with H. parainfluenzae endocarditis.
噬血细胞性淋巴组织细胞增生症（HLH）是一种罕见但严重且可能致命的综合征，其特征是良性巨噬细胞在整个网状内皮系统中增生并激活，伴有噬血细胞现象。该综合征在感染（通常为病毒感染）、恶性肿瘤、风湿性和代谢性疾病背景下获得时，分为原发性（遗传性）或继发性。
我们报告一例HLH并发副流感嗜血杆菌二尖瓣心内膜炎，仅通过抗生素和手术治疗即治愈的病例。我们还回顾了其他与HLH相关的感染性心内膜炎病例报告。
该综合征可能诊断不足。据我们所知，这是首例与副流感嗜血杆菌心内膜炎相关的HLH综合征报告。
