Li Yu-Ying, Mazarakis Thodoris, Shen Yu-Chih, Yang Miao-Chun, Chang En-Ting, Wang Hsiu-Mei
1 Department of Counseling and Clinical Psychology, National Dong Hwa University, Hualien, Taiwan.
2 Department of Psychiatry, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Int J Psychiatry Med. 2016 Aug;51(6):554-562. doi: 10.1177/0091217417696737. Epub 2017 Mar 6.
Background Obstructive sleep apnea involves repeated nocturnal desaturation and sleep fragmentation that leads to poor sleep quality, anxiety, and depression. This study aimed to investigate short- and long-term improvements in the anxiety and depression of patients with different obstructive sleep apnea treatments. Methods This is a prospective, non-randomized hospital-based study evaluated 55 patients (46 male, 9 female) with obstructive sleep apnea. The patients were divided into three groups based on different treatment: uvulopalatopharyngoplasty group, continuous positive airway pressure group, and no treatment group (by their own decision). They completed the Beck Depression Inventory II, Beck Anxiety Inventory, and Pittsburgh Sleep Quality Index before treatment and at one and six months after treatment. Results Compared to the no treatment group, the surgery and continuous positive airway pressure groups had higher body mass index, AHI, and Epworth sleepiness scale, but no difference in Pittsburgh Sleep Quality Index, Chinese Health Questionnaire-12, Beck Depression Inventory II, and Beck Anxiety Inventory. The continuous positive airway pressure and surgery groups still had no improvements in Pittsburgh Sleep Quality Index, Chinese Health Questionnaire-12, Beck Depression Inventory II, and Beck Anxiety Inventory scores one month after treatment. At six months after treatment, the continuous positive airway pressure group had significantly decreased Pittsburgh Sleep Quality Index, Chinese Health Questionnaire-12, Beck Depression Inventory II, and Beck Anxiety Inventory, whereas the surgery group had significant difference in Beck Anxiety Inventory only and the no treatment group still had no significant difference in any of the parameters. Conclusions Continuous positive airway pressure can improve the sleep quality, quality of life, depression, and anxiety of obstructive sleep apnea patients after six months of treatment. However, surgery can significantly improve anxiety only in the same period.
背景 阻塞性睡眠呼吸暂停涉及夜间反复出现的血氧饱和度下降和睡眠片段化，这会导致睡眠质量差、焦虑和抑郁。本研究旨在调查不同阻塞性睡眠呼吸暂停治疗方法对患者焦虑和抑郁的短期及长期改善情况。方法 这是一项基于医院的前瞻性、非随机研究，评估了55例阻塞性睡眠呼吸暂停患者（46例男性，9例女性）。根据不同治疗方法将患者分为三组：悬雍垂腭咽成形术组、持续气道正压通气组和未治疗组（由患者自行决定）。他们在治疗前以及治疗后1个月和6个月完成了贝克抑郁量表第二版、贝克焦虑量表和匹兹堡睡眠质量指数。结果 与未治疗组相比，手术组和持续气道正压通气组的体重指数、呼吸暂停低通气指数和爱泼华嗜睡量表得分更高，但在匹兹堡睡眠质量指数、中文版健康问卷-12、贝克抑郁量表第二版和贝克焦虑量表方面无差异。治疗1个月后，持续气道正压通气组和手术组在匹兹堡睡眠质量指数、中文版健康问卷-12、贝克抑郁量表第二版和贝克焦虑量表得分方面仍无改善。治疗6个月后，持续气道正压通气组的匹兹堡睡眠质量指数、中文版健康问卷-12、贝克抑郁量表第二版和贝克焦虑量表显著下降，而手术组仅在贝克焦虑量表方面有显著差异，未治疗组在任何参数方面仍无显著差异。结论 持续气道正压通气治疗6个月后可改善阻塞性睡眠呼吸暂停患者的睡眠质量、生活质量、抑郁和焦虑。然而，手术仅在同一时期能显著改善焦虑。
