Eilaghi Armin, Baig Sameer, Zhang Yucheng, Zhang Junjie, Karanicolas Paul, Gallinger Steven, Khalvati Farzad, Haider Masoom A
Department of Medical Imaging and Sunnybrook Research Institute, Sunnybrook Health Sciences Center, University of Toronto, 2075 Bayview Ave., Room Rm AG 46, Toronto, M4N 3 M5, ON, Canada.
Mechanical Engineering Department, Australian College of Kuwait, Kuwait City, Kuwait.
BMC Med Imaging. 2017 Jun 19;17(1):38. doi: 10.1186/s12880-017-0209-5.
To assess whether CT-derived texture features predict survival in patients undergoing resection for pancreatic ductal adenocarcinoma (PDAC).
Thirty patients with pre-operative CT from 2007 to 2012 for PDAC were included. Tumor size and five texture features namely uniformity, entropy, dissimilarity, correlation, and inverse difference normalized were calculated. Mann-Whitney rank sum test was used to compare tumor with normal pancreas. Receiver operating characteristics (ROC) analysis, Cox regression and Kaplan-Meier tests were used to assess association of texture features with overall survival (OS).
Uniformity (p < 0.001), entropy (p = 0.009), correlation (p < 0.001), and mean intensity (p < 0.001) were significantly different in tumor regions compared to normal pancreas. Tumor dissimilarity (p = 0.045) and inverse difference normalized (p = 0.046) were associated with OS whereas tumor intensity (p = 0.366), tumor size (p = 0.611) and other textural features including uniformity (p = 0.334), entropy (p = 0.330) and correlation (p = 0.068) were not associated with OS.
CT-derived PDAC texture features of dissimilarity and inverse difference normalized are promising prognostic imaging biomarkers of OS for patients undergoing curative intent surgical resection.
评估CT衍生的纹理特征是否能预测接受胰腺导管腺癌（PDAC）切除术患者的生存率。
纳入2007年至2012年期间30例接受PDAC术前CT检查的患者。计算肿瘤大小以及五个纹理特征，即均匀性、熵、差异性、相关性和归一化逆差。采用曼-惠特尼秩和检验比较肿瘤与正常胰腺。采用受试者工作特征（ROC）分析、Cox回归和Kaplan-Meier检验评估纹理特征与总生存期（OS）的相关性。
与正常胰腺相比，肿瘤区域的均匀性（p < 0.001）、熵（p = 0.009）、相关性（p < 0.001）和平均强度（p < 0.001）有显著差异。肿瘤差异性（p = 0.045）和归一化逆差（p = 0.046）与OS相关，而肿瘤强度（p = 0.366）、肿瘤大小（p = 0.611）以及包括均匀性（p = 0.334）、熵（p = 0.330）和相关性（p = 0.068）在内的其他纹理特征与OS无关。
CT衍生的PDAC差异性和归一化逆差纹理特征是接受根治性手术切除患者OS有前景的预后影像生物标志物。
