Center for Neuroscience Discovery,University of North Texas Health Science Center,Fort Worth,Texas,USA.
Department of Psychiatry,University of North Texas Health Science Center,Fort Worth,Texas,USA.
Int Psychogeriatr. 2017 Oct;29(10):1693-1699. doi: 10.1017/S1041610217001016. Epub 2017 Jun 20.
This study explored the combined impact of depression and inflammation on memory functioning among Mexican-American adults and elders.
Data were analyzed from 381 participants of the Health and Aging Brain study among Latino Elders (HABLE). Fasting serum samples were collected and assayed in duplicate using electrochemiluminesce on the SECTOR Imager 2400A from Meso Scale Discovery. Positive DepE (depression endophenotype) was codified as any score >1 on a five-point scale based on the GDS-30. Inflammation was determined by TNFα levels and categorized by tertiles (1st, 2nd, 3rd). WMS-III LMI and LMII as well as CERAD were utilized as measures of memory. ANOVAs examined group differences between positive DepE and inflammation tertiles with neuropsychological scale scores as outcome variables. Logistic regressions were used to examine level of inflammation and DepE positive status on the risk for MCI.
Positive DepE as well as higher inflammation were both independently found to be associated with lower memory scores. Among DepE positive, those who were high in inflammation (3rd tertile) were found to perform significantly worse on WMS-III LM I (F = 4.75, p = 0.003), WMS-III LM II (F = 8.18, p < 0.001), and CERAD List Learning (F = 17.37, p < 0.001) when compared to those low on inflammation (1st tertile). The combination of DepE positive and highest tertile of inflammation was associated with increased risk for MCI diagnosis (OR = 6.06; 95% CI = 3.9-11.2, p < 0.001).
Presence of elevated inflammation and positive DepE scores increased risk for worse memory among Mexican-American older adults. Additionally, the combination of DepE and high inflammation was associated with increased risk for MCI diagnosis. This work suggests that depression and inflammation are independently associated with worse memory among Mexican-American adults and elders; however, the combination of both increases risk for poorer memory beyond either alone.
本研究探讨了抑郁和炎症对墨西哥裔美国成年人和老年人记忆功能的综合影响。
对拉丁裔老年人健康与老龄化大脑研究（HABLE）中的 381 名参与者的数据进行了分析。采集空腹血清样本，使用 Meso Scale Discovery 的 SECTOR Imager 2400A 进行电化学发光双份检测。根据 GDS-30 五分制，任何得分>1 的被编码为阳性 DepE（抑郁内表型）。炎症通过 TNFα 水平确定，并按三分位数（第 1、2、3 位）分类。WMS-III LMI 和 LMII 以及 CERAD 用作记忆的衡量标准。方差分析检查了阳性 DepE 与炎症三分位组之间的差异，神经心理学量表评分作为因变量。逻辑回归用于检验炎症水平和 DepE 阳性状态对 MCI 风险的影响。
阳性 DepE 以及更高的炎症水平都被发现与较低的记忆评分独立相关。在 DepE 阳性者中，炎症水平较高（第 3 三分位）的患者在 WMS-III LM I（F=4.75，p=0.003）、WMS-III LM II（F=8.18，p<0.001）和 CERAD 列表学习（F=17.37，p<0.001）方面的表现明显差于炎症水平较低的患者（第 1 三分位）。DepE 阳性和炎症最高三分位的组合与 MCI 诊断风险增加相关（OR=6.06；95%CI=3.9-11.2，p<0.001）。
炎症水平升高和 DepE 评分阳性增加了墨西哥裔美国老年人记忆障碍的风险。此外，DepE 和高炎症的组合与 MCI 诊断风险增加相关。本研究表明，抑郁和炎症与墨西哥裔美国成年人和老年人的记忆障碍独立相关；然而，两者的组合比任何一种单独的情况更增加了记忆障碍的风险。
