Johnson Leigh A, Gamboa Adriana, Vintimilla Raul, Edwards Melissa, Hall James, Weiser Brent, Yadav Menaka, Dickensheets Tony, O'Bryant Sid E
Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, TX, USA.
Department of Psychiatry, University of North Texas Health Science Center, Fort Worth, TX, USA.
J Alzheimers Dis. 2016 Jul 25;54(1):201-6. doi: 10.3233/JAD-150743.
Late life depression is a prodromal feature and a risk factor for Alzheimer's disease (AD) and mild cognitive impairment (MCI). We identified five items in the Geriatric Depression scale (DepE) that are important as a risk for MCI and AD: memory problems, feeling blue, crying, feeling worthless, and trouble concentrating.
Our goal was to examine the relationship between DepE and cognition in a cohort of Mexican Americans.
Data from 317 Mexican Americans from the HABLE study were analyzed. DepE scores were dichotomized into two groups: endorsement of 1 item or less, and endorsement of 2 or more items. Cognition was assessed via neuropsychological tests, and diagnosis was based on consensus review. We utilized linear regression to examine the association between DepE and cognitive performance, and logistic regression to examine the utility of DepE in predicting MCI. To examine the impact of DepE on memory over 12 months, we performed ANOVA analysis.
Elevated DepE scores were associated with poorer performance on various measures of memory and cognition, but not executive or visual spatial skills. Over 12 months, we found a decline in immediate memory among women but not men. Those with high scores were 4 times more likely to have MCI. ANOVA of total scores revealed differences between groups on immediate memory (p < 0.05) in women, with no significant differences on delay recall in either gender.
DepE can be utilized in Mexican Americans to identify those at risk of memory related cognitive decline.
晚年抑郁症是阿尔茨海默病（AD）和轻度认知障碍（MCI）的前驱特征及危险因素。我们在老年抑郁量表（DepE）中确定了五个项目，它们作为MCI和AD的危险因素很重要：记忆问题、情绪低落、哭泣、感觉毫无价值以及注意力不集中。
我们的目标是在一组墨西哥裔美国人中研究DepE与认知之间的关系。
对来自HABLE研究的317名墨西哥裔美国人的数据进行了分析。DepE得分被分为两组：认可1项或更少项目，以及认可2项或更多项目。通过神经心理学测试评估认知，诊断基于共识审查。我们使用线性回归来研究DepE与认知表现之间的关联，并使用逻辑回归来研究DepE在预测MCI方面的效用。为了研究DepE对12个月内记忆的影响，我们进行了方差分析。
DepE得分升高与各种记忆和认知测量指标的较差表现相关，但与执行或视觉空间技能无关。在12个月的时间里，我们发现女性的即时记忆有所下降，而男性则没有。高分者患MCI的可能性高出4倍。总分的方差分析显示，女性在即时记忆方面存在组间差异（p<0.05），而在延迟回忆方面，两性均无显著差异。
DepE可用于墨西哥裔美国人，以识别那些有记忆相关认知衰退风险的人。
