从穿心莲中分离得到的两种新二萜内酯。
Two new diterpenoid lactones isolated from Andrographis paniculata.
作者信息
Wang Gui-Yang, Wen Ting, Liu Fei-Fei, Tian Hai-Yan, Chun-Lin Fan, Huang Xiao-Jun, Ye Wen-Cai, Wang Ying
机构信息
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China; JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, College of Pharmacy, Jinan University, Guangzhou 510632, China.
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
出版信息
Chin J Nat Med. 2017 Jun;15(6):458-462. doi: 10.1016/S1875-5364(17)30068-7.
In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside (1) and 14-deoxy-15-methoxy-andrographolide (2), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated by combination of NMR, MS, and chemical methods. The configurations of 1 and 2 were established based on the analysis of ROESY data and single crystal X-ray diffraction experiment.
在本研究中，从穿心莲的地上部分分离出两种新的二萜内酯，3-脱氧穿心莲苷（1）和14-脱氧-15-甲氧基穿心莲内酯（2）。通过核磁共振（NMR）、质谱（MS）和化学方法相结合对其结构进行了阐明。基于旋转坐标系核Overhauser效应光谱（ROESY）数据的分析和单晶X射线衍射实验确定了1和2的构型。
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