Hossain Sanower, Urbi Zannat, Karuniawati Hidayah, Mohiuddin Ramisa Binti, Moh Qrimida Ahmed, Allzrag Akrm Mohamed Masaud, Ming Long Chiau, Pagano Ester, Capasso Raffaele
Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia, Kuantan 25200, Pahang, Malaysia.
Department of Industrial Biotechnology, Faculty of Industrial Sciences & Technology, Universiti Malaysia Pahang, Kuantan 26300, Pahang, Malaysia.
Life (Basel). 2021 Apr 16;11(4):348. doi: 10.3390/life11040348.
Infectious disease (ID) is one of the top-most serious threats to human health globally, further aggravated by antimicrobial resistance and lack of novel immunization options. (Burm. f.) Wall. ex Nees and its metabolites have been long used to treat IDs. Andrographolide, derived from can inhibit invasive microbes virulence factors and regulate the host immunity. Controlled clinical trials revealed that treatment is safe and efficacious for acute respiratory tract infections like common cold and sinusitis. Hence, , mainly andrographolide, could be considered as an excellent candidate for antimicrobial drug development. Considering the importance, medicinal values, and significant role as antimicrobial agents, this study critically evaluated the antimicrobial therapeutic potency of and its metabolites, focusing on the mechanism of action in inhibiting invasive microbes and biofilm formation. A critical evaluation of the secondary metabolites with the aim of identifying pure compounds that possess antimicrobial functions has further added significant values to this study. Notwithstanding that is a promising source of antimicrobial agents and safe treatment for IDs, further empirical research is warranted.
传染病是全球对人类健康最严重的威胁之一，抗菌药物耐药性和缺乏新型免疫接种选择进一步加剧了这一威胁。（缅甸）Wall. ex Nees及其代谢产物长期以来一直用于治疗传染病。穿心莲内酯，源自[原文此处缺失相关植物名称]，可抑制侵袭性微生物的毒力因子并调节宿主免疫力。对照临床试验表明，[原文此处缺失相关药物名称]治疗对普通感冒和鼻窦炎等急性呼吸道感染安全有效。因此，[原文此处缺失相关药物名称]，主要是穿心莲内酯，可被视为抗菌药物开发的优秀候选物。考虑到其重要性、药用价值以及作为抗菌剂的重要作用，本研究严格评估了[原文此处缺失相关药物名称]及其代谢产物的抗菌治疗效力，重点关注其抑制侵袭性微生物和生物膜形成的作用机制。对次生代谢产物进行严格评估以鉴定具有抗菌功能的纯化合物，进一步为该研究增添了重要价值。尽管[原文此处缺失相关药物名称]是抗菌剂的有希望的来源和治疗传染病的安全药物，但仍需要进一步的实证研究。
