Nobou F, Besson J, Rostene W, Rosselin G
Brain Res. 1985 Jun;352(2):296-301. doi: 10.1016/0165-3806(85)90118-x.
The ontogeny of the vasoactive intestinal peptide (VIP) and somatostatin (SRIF) was studied in various structures of the rat central nervous system (CNS), using specific radioimmunoassays. The effect of adrenal corticoids on the concentration of both peptides was investigated during the development of the rat from 3 days before birth to 2 months after birth. The evolution of both peptides was different since SRIF was found before birth in each structure tested while VIP appeared only after birth in the same structures. However, after birth the ontogeny of VIP and SRIF was quite similar and the maximum concentration of both peptides occurred between day 14 and day 21. Hypercorticism (implant of corticosterone) and hypocorticism (Metyrapone injections) modified the postnatal evolution of both peptides, suggesting that corticoids play an important role in the brain developmental patterns of VIP and SRIF.
利用特异性放射免疫分析法，研究了大鼠中枢神经系统（CNS）不同结构中血管活性肠肽（VIP）和生长抑素（SRIF）的个体发生。在大鼠从出生前3天到出生后2个月的发育过程中，研究了肾上腺皮质激素对这两种肽浓度的影响。由于在每个测试结构中出生前就发现了SRIF，而VIP在相同结构中仅在出生后出现，因此这两种肽的演变是不同的。然而，出生后VIP和SRIF的个体发生非常相似，两种肽的最大浓度出现在第14天到第21天之间。高皮质醇血症（植入皮质酮）和低皮质醇血症（注射甲吡酮）改变了这两种肽的出生后演变，表明皮质激素在VIP和SRIF的脑发育模式中起重要作用。
