Nakamura H, Moroji T, Nagase H, Okazawa T, Okada A
Department of Public Health, Kanazawa University School of Medicine, Japan.
Eur J Appl Physiol Occup Physiol. 1994;68(1):62-7. doi: 10.1007/BF00599243.
To clarify the role of vasoactive intestinal polypeptide (VIP) and somatostatin, somatotropin-release inhibiting factor, (SRIF) neurons in the response to organisms to noise or whole-body vibration stress, VIP- and SRIF-like immunoreactivity were determined in various regions of the rat brain following exposure for 90 min to noise (broad band, 102 dB) or whole-body vibration (20 Hz, 4.0 g). Both noise and whole-body vibration significantly increased VIP-like immunoreactivity in the amygdala. A significant reduction of VIP-like immunoreactivity in the hippocampus was induced only by whole-body vibration. On the other hand, SRIF-like immunoreactivity was decreased significantly in the hypothalamus and increased significantly in the amygdala by noise and whole-body vibration, respectively. The present findings would seem to indicate that the amygdalofugal VIP neural system is involved in regulating hypothalamic and pituitary hormone secretions in non-specific reactions to stress. Responses of hippocampal VIP and the amygdalofugal SRIF to whole-body vibration stress are assumed to be activated as specific reactions to the stress.
为阐明血管活性肠肽（VIP）和生长抑素（促生长激素释放抑制因子，SRIF）神经元在机体对噪声或全身振动应激反应中的作用，在大鼠暴露于噪声（宽带，102分贝）或全身振动（20赫兹，4.0克）90分钟后，测定其大脑各区域中VIP样和SRIF样免疫反应性。噪声和全身振动均显著增加杏仁核中的VIP样免疫反应性。仅全身振动可导致海马体中VIP样免疫反应性显著降低。另一方面，噪声和全身振动分别使下丘脑的SRIF样免疫反应性显著降低和杏仁核中的SRIF样免疫反应性显著增加。目前的研究结果似乎表明，杏仁核传出VIP神经系统参与调节非特异性应激反应中下丘脑和垂体激素的分泌。海马体VIP和杏仁核传出SRIF对全身振动应激的反应被认为是对应激的特异性反应而被激活。
