Yassa R, Ghadirian A M, Schwartz G
Can J Psychiatry. 1985 Aug;30(5):344-7. doi: 10.1177/070674378503000508.
Tardive dyskinesia (TD) is an involuntary movement disorder predominantly the result of long-term neuroleptic administration. Several factors have been studied with conflicting results. In this paper, the authors compare a group of 17 TD patients with 17 non-TD controls to delineate possible etiological factors in the development of this syndrome. Factors like total neuroleptic and antiparkinsonian medication intake and organicity were not different in the groups. Only drug-free periods in the past history of TD patients were found to be statistically more significant (P less than 0.025) in these patients than in non-TD controls.
迟发性运动障碍（TD）是一种主要由长期服用抗精神病药物导致的非自主性运动障碍。已经对若干因素进行了研究，但结果相互矛盾。在本文中，作者将一组17例迟发性运动障碍患者与17例非迟发性运动障碍对照者进行比较，以确定该综合征发生过程中可能的病因因素。两组在抗精神病药物和抗帕金森病药物的总摄入量以及器质性方面的因素并无差异。仅发现迟发性运动障碍患者过去的无药期在统计学上比非迟发性运动障碍对照者更显著（P小于0.025）。
