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聚合物纳米颗粒:药物递送的有前景平台。

Polymeric nanoparticles: Promising platform for drug delivery.

作者信息

El-Say Khalid M, El-Sawy Hossam S

机构信息

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Egyptian Russian University, Badr City, Cairo, Egypt.

出版信息

Int J Pharm. 2017 Aug 7;528(1-2):675-691. doi: 10.1016/j.ijpharm.2017.06.052. Epub 2017 Jun 16.

Abstract

Nano medicine had viewed countless breakthroughs in drug delivery implementations. The main objective of nanotechnology application in delivering and carrying many promising therapeutics is to assure drugs carriage to their action sites, to maximize the pharmacological desired influence of remedies and to overcome their limitations and drawbacks that would hinder the required effectiveness. One of these applications was the particulates type of nano-range in size and tremendous impact in achievement. About this specific diversity of particulates, the different elaboration methodologies, mandatory and elementary components for design, and examples of splendid success stories for these particulates were emphasized in this humble review. Challenges such as oral delivery probability for peptide moieties and enhancement the harshly passage process of drugs across the blood brain barriers were accepted and defeated by the almost insurmountable latterly mentioned particulates. Behold, the polymeric nanoparticles.

摘要

纳米医学在药物递送应用方面取得了无数突破。纳米技术应用于递送和携带许多有前景的治疗药物的主要目标是确保药物运送到其作用部位,最大化药物的药理预期效果,并克服可能阻碍所需疗效的局限性和缺点。其中一种应用是纳米级尺寸的颗粒类型,在实现过程中具有巨大影响。关于这种颗粒的特定多样性,本文简要综述强调了不同的制备方法、设计所需的基本要素以及这些颗粒的成功范例。诸如肽部分的口服递送可能性以及增强药物穿过血脑屏障的艰难过程等挑战,几乎无法克服的上述颗粒却能够应对并战胜。看呐,就是聚合物纳米颗粒。

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