Oatts Julius T, Robbins Julie A, de Alba Campomanes Alejandra G
Department of Ophthalmology, University of California, San Francisco, San Francisco, California.
Stanford Cancer Institute, Stanford University, Palo Alto, California.
J AAPOS. 2017 Aug;21(4):309-312. doi: 10.1016/j.jaapos.2017.06.008. Epub 2017 Jun 17.
To measure orbital volume using serial magnetic resonance imaging (MRI) scans to determine the effect of enucleation on orbital growth over time.
The medical records of patients who underwent unilateral enucleation for retinoblastoma with a minimum of 2 MRIs were retrospectively reviewed. Orbital asymmetry was calculated using MRI measurements. Nonlinear and linear mixed effect regression models were used to predict the effect of age at time of enucleation on degree of orbital asymmetry.
A total of 27 patients were included (mean age at enucleation, 2 years; range, 2.5 months to 5 years). Age at scan (P = 0.046) and age at enucleation (P = 0.0006) were found to have a significant effect on orbital asymmetry. Change in orbital asymmetry over time was more pronounced after enucleation in children enucleated at <1 (P < 0.0001) or <2 years of age (P = 0.0109). Younger age at enucleation was associated with a greater degree of asymmetry over time, although this effect was extinguished for patients enucleated after the age of 3 years.
In patients with retinoblastoma, enucleation with orbital implant before 3 years of age has a significant effect on orbital volume asymmetry. After the age of 3, this effect appears to be less detrimental to the degree of orbital asymmetry.
使用系列磁共振成像（MRI）扫描测量眼眶容积，以确定眼球摘除术随时间推移对眼眶生长的影响。
回顾性分析接受视网膜母细胞瘤单侧眼球摘除术且至少有2次MRI检查的患者的病历。使用MRI测量值计算眼眶不对称性。采用非线性和线性混合效应回归模型预测眼球摘除时的年龄对眼眶不对称程度的影响。
共纳入27例患者（眼球摘除时的平均年龄为2岁；范围为2.5个月至5岁）。发现扫描时的年龄（P = 0.046）和眼球摘除时的年龄（P = 0.0006）对眼眶不对称性有显著影响。对于1岁以下（P < 0.0001）或2岁以下（P = 0.0109）接受眼球摘除术的儿童，眼球摘除术后眼眶不对称性随时间的变化更为明显。眼球摘除时年龄越小，随时间推移不对称程度越大，不过对于3岁以后接受眼球摘除术的患者，这种影响消失。
在视网膜母细胞瘤患者中，3岁前植入眼眶植入物的眼球摘除术对眼眶容积不对称性有显著影响。3岁以后，这种影响似乎对眼眶不对称程度的损害较小。
