血清型 3 肺炎链球菌通过荚膜转换实现对青霉素耐药性的基因组进化。
Genome Evolution to Penicillin Resistance in Serotype 3 Streptococcus pneumoniae by Capsular Switching.
机构信息
Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Department of Bacteriology, Gunma University Graduate School of Medicine, Gunma, Japan.
出版信息
Antimicrob Agents Chemother. 2017 Aug 24;61(9). doi: 10.1128/AAC.00478-17. Print 2017 Sep.
Abstract
isolates of serotype 3 were collected from cases of invasive pneumococcal disease ( = 124) throughout Japan between April 2010 and March 2013. A penicillin-resistant (PRSP) isolate from an adult patient, strain KK0981 of serotype 3, was identified among these strains. Whole-genome analysis characterized this PRSP as a recombinant strain derived from PRSP of serotype 23F with the locus (20.3 kb) replaced by that of a penicillin-susceptible strain of serotype 3.
摘要
2010 年 4 月至 2013 年 3 月期间，从日本各地侵袭性肺炎球菌病（=124）病例中采集了 3 型分离株。在这些菌株中鉴定出一株来自成人患者的耐青霉素（PRSP）分离株，血清型 3 菌株 KK0981。全基因组分析表明，该 PRSP 是由血清型 23F 的 PRSP 重组而来，其 基因座（20.3 kb）被血清型 3 的青霉素敏感株所取代。
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