甲基苯丙胺神经毒性的分子、行为和生理后果：对治疗的启示。
Molecular, Behavioral, and Physiological Consequences of Methamphetamine Neurotoxicity: Implications for Treatment.
作者信息
Moszczynska Anna, Callan Sean Patrick
机构信息
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan
Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan.
出版信息
J Pharmacol Exp Ther. 2017 Sep;362(3):474-488. doi: 10.1124/jpet.116.238501. Epub 2017 Jun 19.
Abstract
Understanding the relationship between the molecular mechanisms underlying neurotoxicity of high-dose methamphetamine (METH) and related clinical manifestations is imperative for providing more effective treatments for human METH users. This article provides an overview of clinical manifestations of METH neurotoxicity to the central nervous system and neurobiology underlying the consequences of administration of neurotoxic METH doses, and discusses implications of METH neurotoxicity for treatment of human abusers of the drug.
摘要
了解高剂量甲基苯丙胺（METH）神经毒性的分子机制与相关临床表现之间的关系，对于为甲基苯丙胺使用者提供更有效的治疗至关重要。本文概述了甲基苯丙胺对中枢神经系统的神经毒性临床表现以及给予神经毒性剂量甲基苯丙胺所产生后果的神经生物学机制，并讨论了甲基苯丙胺神经毒性对药物滥用者治疗的影响。
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