Yao Wang, Zhang Hao, Li Shuaiqi, Song Sensen, Ye Zheng, Zhou Xiaolin
School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.
School of Education and Psychology, Chengdu Normal University, Chengdu, China.
Front Psychiatry. 2024 Sep 27;15:1458509. doi: 10.3389/fpsyt.2024.1458509. eCollection 2024.
The ability to maintain and manipulate sequential information in working memory, referred to as sequential working memory, plays a vital role in our daily life. While research has shown that methamphetamine abuse affects the neural substrates and the overall functioning of working memory, its specific impact on sequential working memory remains unclear. In this study, we asked 62 abstinent methamphetamine-dependent participants and 59 control participants to complete a digit ordering task in which they saw four digits one-by-one over time and subsequently rearranged them in ascending order. The four digits were presented either randomly in the experimental condition or in ascending order in the control condition. Results show that methamphetamine-dependent participants performed worse than the controls in the experimental condition in which sequential working memory was needed to complete the task, but not in the control condition in which only short-term memory was needed. This finding demonstrates that methamphetamine abuse impairs sequential working memory.
在工作记忆中维持和处理序列信息的能力，即序列工作记忆，在我们的日常生活中起着至关重要的作用。虽然研究表明甲基苯丙胺滥用会影响工作记忆的神经基质和整体功能，但其对序列工作记忆的具体影响仍不清楚。在本研究中，我们让62名戒除甲基苯丙胺依赖的参与者和59名对照参与者完成一项数字排序任务，在该任务中，他们随着时间逐个看到四个数字，随后将它们按升序重新排列。在实验条件下，四个数字随机呈现；在对照条件下，四个数字按升序呈现。结果表明，在需要序列工作记忆来完成任务的实验条件下，甲基苯丙胺依赖的参与者表现比对照组差，但在只需要短期记忆的对照条件下并非如此。这一发现表明甲基苯丙胺滥用会损害序列工作记忆。
