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The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia.

作者信息

Rio-Machin A, Gómez-López G, Muñoz J, Garcia-Martinez F, Maiques-Diaz A, Alvarez S, Salgado R N, Shrestha M, Torres-Ruiz R, Haferlach C, Larráyoz M J, Calasanz M J, Fitzgibbon J, Cigudosa J C

机构信息

Molecular Cytogenetics Group, Human Cancer Genetics Programme, Centro Nacional Investigaciones Oncologicas (CNIO), Madrid, Spain.

Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, UK.

出版信息

Leukemia. 2017 Sep;31(9):2000-2005. doi: 10.1038/leu.2017.194. Epub 2017 Jun 20.

DOI:10.1038/leu.2017.194
PMID:28630438
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5596207/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea4/5596207/60c563dfa11e/leu2017194f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea4/5596207/d08417c837ac/leu2017194f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea4/5596207/60c563dfa11e/leu2017194f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea4/5596207/d08417c837ac/leu2017194f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ea4/5596207/60c563dfa11e/leu2017194f2.jpg

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本文引用的文献

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Cancer Cell. 2016 Dec 12;30(6):863-878. doi: 10.1016/j.ccell.2016.10.019. Epub 2016 Nov 23.
2
Chromatin-prebound Crm1 recruits Nup98-HoxA9 fusion to induce aberrant expression of Hox cluster genes.与染色质预结合的Crm1招募Nup98-HoxA9融合蛋白以诱导Hox基因簇的异常表达。
Elife. 2016 Jan 7;5:e09540. doi: 10.7554/eLife.09540.
3
The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia.
髓系恶性肿瘤中的NUP98致癌融合：分子机制与治疗机会的最新进展
Hemasphere. 2024 Sep 25;8(9):e70013. doi: 10.1002/hem3.70013. eCollection 2024 Sep.
4
Clinical features and prognosis of patients with myeloid neoplasms harboring t(7;11)(p15;p15) translocation: a single-center retrospective study.伴有 t(7;11)(p15;p15) 易位的髓系肿瘤患者的临床特征和预后：一项单中心回顾性研究。
BMC Cancer. 2024 Aug 5;24(1):955. doi: 10.1186/s12885-024-12679-8.
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Therapeutic targeting in pediatric acute myeloid leukemia with aberrant HOX/MEIS1 expression.治疗靶向治疗伴有异常 HOX/MEIS1 表达的小儿急性髓系白血病。
Eur J Med Genet. 2023 Dec;66(12):104869. doi: 10.1016/j.ejmg.2023.104869. Epub 2023 Oct 29.
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Enhancer biology and enhanceropathies.增强子生物学与增强子病。
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Blood. 2014 Feb 27;123(9):1341-52. doi: 10.1182/blood-2013-03-488114. Epub 2014 Jan 10.
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Onco Targets Ther. 2013 Nov 15;6:1613-24. doi: 10.2147/OTT.S30773. eCollection 2013.
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N Engl J Med. 2013 May 30;368(22):2059-74. doi: 10.1056/NEJMoa1301689. Epub 2013 May 1.