Gupta V K
Colorado State University, Fort Collins, Colorado 80523, USA.
Physica A. 2017 Feb 15;468:244-251. doi: 10.1016/j.physa.2016.10.098. Epub 2016 Nov 11.
Many complex biological processes such as cell differentiation, cell proliferation, and cell motility are governed by cell signaling. This mode of intercellular communication is of paramount importance for tissue function and ultimately for entire organism. In intercellular communication cells secrete signaling molecules such as cyto/chemokines which diffuse through the surrounding medium and eventually bind to receptors on other cells whereby the signal transduction is completed. An accurate estimation of the effective communication distances and the time scale on which signaling takes place are important for the interpretation of cell and organ physiology and ultimately in the effective and efficient chemotactically driven tissue engineering. The present study uses a solitary cell model incorporating degradation of secreted molecules to estimate the effective communication distances and the time scale on which signaling takes place. We demonstrate through our model that in presence of degradation the effective communication distances are significantly reduced.
许多复杂的生物过程，如细胞分化、细胞增殖和细胞运动，都受细胞信号传导的调控。这种细胞间通讯方式对于组织功能乃至整个生物体至关重要。在细胞间通讯中，细胞分泌细胞因子/趋化因子等信号分子，这些分子通过周围介质扩散，最终与其他细胞上的受体结合，从而完成信号转导。准确估计有效通讯距离以及信号传导发生的时间尺度，对于理解细胞和器官生理学以及最终在有效且高效的趋化驱动组织工程中都很重要。本研究使用一个包含分泌分子降解的单细胞模型来估计有效通讯距离以及信号传导发生的时间尺度。我们通过模型证明，在存在降解的情况下，有效通讯距离会显著缩短。
