Jiang Yan, Zhao Chen-Yang, Cheng Li-Chun, Xu Bing, Lv Hui-Yi
Department of Pharmaceuticals, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027 People's Republic of China.
Hered Cancer Clin Pract. 2017 Jun 13;15:8. doi: 10.1186/s13053-017-0068-7. eCollection 2017.
Adenosine diphosphate (ADP)-ribosylation factor-like tumour suppressor gene 1() might be associated with an increased risk of several types of familial cancers. However, previous studies have shown that cancer susceptibility is not completely consistent with polymorphisms, and the precise mechanism remains unknown. Therefore, we conducted a meta-analysis of case-control studies by searching the PubMed, Embase, OVID, Science Direct and Chinese National Knowledge Infrastructure (CNKI) databases. In total, 12 studies met the inclusion criteria and were included in this meta-analysis. Statistical analyses were performed using STATA 11.0 software. Overall, the Cys148Arg T > C variant significantly increased cancer risk (CC vs. TT: OR = 1.27, 95% CI = 1.15-1.41, < 0.05). The stratification indicated that the Cys148Arg variant is significantly associated with sporadic cancer (CC vs. TT: OR = 1.36, 95% CI = 1.18-1.55) and familial cancer (CC vs. TT: OR = 1.26, 95% CI = 1.12-1.43). Trp149Stop, Pro131Leu, Ser99Ser and Leu132Leu were not correlated with cancer susceptibility. Based on these results, we demonstrated that the Cys148Arg polymorphism is associated with an increased risk of sporadic cancer and familial cancer, and there were no associations between the other four SNPs (i.e., Trp149Stop, Pro131Leu, Ser99Ser and Leu132Leu) and cancer risk.
二磷酸腺苷（ADP）-核糖基化因子样肿瘤抑制基因1（）可能与多种类型的家族性癌症风险增加有关。然而，先前的研究表明，癌症易感性与多态性并不完全一致，确切机制仍不清楚。因此，我们通过检索PubMed、Embase、OVID、Science Direct和中国国家知识基础设施（CNKI）数据库，对病例对照研究进行了荟萃分析。共有12项研究符合纳入标准并被纳入本荟萃分析。使用STATA 11.0软件进行统计分析。总体而言，Cys148Arg T>C变体显著增加了癌症风险（CC与TT相比：OR = 1.27，95%CI = 1.15 - 1.41，<0.05）。分层分析表明，Cys148Arg变体与散发性癌症（CC与TT相比：OR = 1.36，95%CI = 1.18 - 1.55）和家族性癌症（CC与TT相比：OR = 1.26，95%CI = 1.12 - 1.43）显著相关。Trp149Stop、Pro131Leu、Ser99Ser和Leu132Leu与癌症易感性无关。基于这些结果，我们证明Cys148Arg多态性与散发性癌症和家族性癌症风险增加有关，而其他四个单核苷酸多态性（即Trp149Stop、Pro131Leu、Ser99Ser和Leu132Leu）与癌症风险之间没有关联。
