Orb Quinn, Orlandi Richard R, Alt Jeremiah A
Division of Head and Neck Surgery, Rhinology-Sinus & Skull Base Surgery Program, Department of Surgery; University of Utah, Salt Lake City, UT, U.S.A.
Laryngoscope Investig Otolaryngol. 2017 Apr;2(2):46-52. doi: 10.1002/lio2.60. Epub 2017 Feb 2.
Poor sleep has significant effects on health contributing to increased morbidity and mortality. The direct and indirect costs of sleep dysfunction total well in to the billions of dollars annually in the US. Chronic rhinosinusitis (CRS) affects up to 16% of the US population and has been linked to poor sleep quality with up to three quarters of patients with CRS reporting poor sleep quality. There is a growing body of literature evaluating the relationship between sleep and CRS. In this review, we organize and present the current knowledge on the associations between sleep and CRS as well as identify areas for further investigation.
A structured literature search from 1946 to 2016 was conducted in the English language using OVID MEDLINE database, PubMed and EMBASE.
Abstracts were reviewed for relevance and appropriate studies were included in the narrative review.
Studies were analyzed and discussed as they pertained to the following categories of CRS and sleep: (1) subjective measures of sleep dysfunction, (2) objective measures of sleep dysfunction, and (3) outcomes on sleep quality following treatment of CRS. Articles on the pathophysiology of sleep dysfunction in CRS were separately reviewed.
An evolving body of research demonstrates that quality of sleep is compromised in the majority of patients with CRS. Following treatment of CRS, there is significant improvement in subjective sleep quality, but additional research investigating objective measures following treatment is still needed. Additionally, further investigation is required to better elucidate the underlying pathophysiology of the relationship between sleep dysfunction and CRS.
睡眠不佳对健康有重大影响，会导致发病率和死亡率上升。在美国，睡眠功能障碍的直接和间接成本每年总计高达数十亿美元。慢性鼻-鼻窦炎（CRS）影响着多达16%的美国人口，并且与睡眠质量差有关，多达四分之三的CRS患者报告睡眠质量差。评估睡眠与CRS之间关系的文献越来越多。在本综述中，我们整理并呈现了关于睡眠与CRS之间关联的现有知识，并确定了需要进一步研究的领域。
使用OVID MEDLINE数据库、PubMed和EMBASE对1946年至2016年的英文文献进行了结构化检索。
对摘要进行相关性审查，并将适当的研究纳入叙述性综述。
根据研究与以下CRS和睡眠类别相关的情况进行分析和讨论：（1）睡眠功能障碍的主观测量，（2）睡眠功能障碍的客观测量，以及（3）CRS治疗后睡眠质量的结果。关于CRS中睡眠功能障碍病理生理学的文章进行了单独审查。
越来越多的研究表明，大多数CRS患者的睡眠质量受到损害。CRS治疗后，主观睡眠质量有显著改善，但仍需要更多研究来调查治疗后的客观测量情况。此外，需要进一步研究以更好地阐明睡眠功能障碍与CRS之间关系的潜在病理生理学。
