Virgin Frank W
Division of Pediatric Otolaryngology, Department of Otolaryngology Vanderbilt University Nashville Tennessee.
Laryngoscope Investig Otolaryngol. 2017 May 31;2(5):276-280. doi: 10.1002/lio2.78. eCollection 2017 Oct.
Chronic rhinosinusitis and nasal polyposis are common conditions in cystic fibrosis (CF). Approximately 2-3% of pediatric CF patients per year have sinus disease requiring surgery. It has been well established that there is a significant negative impact on quality of life associated with chronic rhinosinusitis (CRS) in the non-CF patient population. However, the impact of CRS on the pediatric CF population remains uncertain. The purpose of this article is to review the current state of outcome measures for CRS in pediatric CF patients.
PubMed and EMBASE literature review.
PubMed and EMBASE electronic databases were searched using Boolean searches that incorporated mesh headings and plain language for quality of life, symptom evaluation, pediatric patients, and sinusitis/rhinosinusitis. Studies were included if the study primarily evaluated a pediatric Cystic Fibrosis-Chronic Rhinosinusitis (CF-CRS) population and the primary outcome measure was quality of life evaluation.
The search yielded 34 unique articles. A total of 7 articles met inclusion criteria.
Despite the high frequency of chronic rhinosinusitis in the pediatric CF patient population, its impact on quality of life is not well understood. Currently there is a lack of a validated disease specific quality of life instruments available to assess the impact of CRS on the pediatric CF patient population.
慢性鼻-鼻窦炎和鼻息肉病在囊性纤维化（CF）患者中很常见。每年约有2%-3%的儿科CF患者患有需要手术治疗的鼻窦疾病。在非CF患者群体中，慢性鼻-鼻窦炎（CRS）对生活质量有显著负面影响，这一点已得到充分证实。然而，CRS对儿科CF患者群体的影响仍不明确。本文旨在综述儿科CF患者CRS结局指标的现状。
PubMed和EMBASE文献综述。
使用布尔检索在PubMed和EMBASE电子数据库中进行检索，检索词包含生活质量、症状评估、儿科患者以及鼻窦炎/鼻-鼻窦炎的主题词和普通语言。如果研究主要评估儿科囊性纤维化-慢性鼻-鼻窦炎（CF-CRS）患者群体，且主要结局指标为生活质量评估，则纳入该研究。
检索得到34篇独特的文章。共有7篇文章符合纳入标准。
尽管儿科CF患者群体中慢性鼻-鼻窦炎的发病率很高，但其对生活质量的影响尚未得到充分了解。目前缺乏经过验证的疾病特异性生活质量工具来评估CRS对儿科CF患者群体的影响。
5级。
