Broyd Christopher J, Rigo Fausto, Davies Justin
Imperial College London, London, UK.
National Heart and Lung Institute, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK.
Int J Cardiovasc Imaging. 2017 Jul;33(7):1061-1068. doi: 10.1007/s10554-017-1185-0. Epub 2017 Jun 19.
Wave intensity analysis is calculated from simultaneously acquired measures of pressure and flow. Its mathematical computation produces a profile that provides quantitative information on the energy exchange driving blood flow acceleration and deceleration. Within the coronary circulation it has proven most useful in describing the wave that originates from the myocardium and that is responsible for driving the majority of coronary flow, labelled the backward decompression wave. Whilst this wave has demonstrated valuable insights into the pathogenic processes of a number of disease states, its measurement is hampered by its invasive necessity. However, recent work has used transthoracic echocardiography and an established measures of central aortic pressure to produce coronary flow velocity and pressure waveforms respectively. This has allowed a non-invasive measure of coronary wave intensity analysis, and in particular the backward decompression wave, to be calculated. It is anticipated that this will allow this tool to become more applicable and widespread, ultimately moving it from the research to the clinical domain.
波强度分析是根据同时采集的压力和流量测量值计算得出的。其数学计算产生一个剖面图，该剖面图提供了关于驱动血流加速和减速的能量交换的定量信息。在冠状动脉循环中，它已被证明在描述源自心肌并负责驱动大部分冠状动脉血流的波（标记为反向减压波）方面最为有用。虽然这个波已经为许多疾病状态的致病过程提供了有价值的见解，但其测量因其侵入性的必要性而受到阻碍。然而，最近的研究使用经胸超声心动图和一种既定的中心主动脉压测量方法，分别产生冠状动脉流速和压力波形。这使得能够对冠状动脉波强度分析，特别是反向减压波进行非侵入性测量。预计这将使该工具更具适用性和广泛应用，最终将其从研究领域转移到临床领域。
