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一种治疗干眼症(角结膜干燥症)的新疗法:解剖学可行性研究。

A novel treatment for keratitis sicca (Dry eye): Anatomical feasibility study.

作者信息

Iwanaga Joe, Watanabe Koichi, Kusukawa Jingo, Fisahn Christian, Alonso Fernando, Oskouian Rod J, Tubbs R Shane

机构信息

Seattle Science Foundation, Seattle, Washington.

Department of Anatomy, Kurume University School of Medicine, Kurume, Fukuoka, 830-0011, Japan.

出版信息

Clin Anat. 2017 Sep;30(6):839-843. doi: 10.1002/ca.22946. Epub 2017 Jul 6.

Abstract

Chronic dry eye (keratitis sicca) is a significant problem that in certain populations can result in corneal desiccation and the potential for blindness. Therefore, novel treatments for such disorders might decrease patient morbidity. The present study aimed to investigate a potential treatment for chronic dry eye via a cadaveric feasibility study. On 10 cadaveric sides, the parotid gland branch of the auriculotemporal nerve (ATN) was identified and anastomosed to an anterior superficial temporal branch (STb) of this same nerve. The STb was then transposed anteriorly and sutured to the lacrimal gland. The parotid branch of the ATN was easily identified on all sides. The STb of the ATN was easily identified and mobilized on all sides. This latter nerve had adequate length to be moved to the ipsilateral lacrimal gland on all sides. Rerouting parotid gland secretomotor fibers to the superficial branch of the ATN and then moving this branch to the lacrimal gland is a feasible surgical maneuver based on our cadaveric study. Clinical studies are now necessary to show utility of this procedure in patients with chronic dry eye. Clin. Anat. 30:839-843, 2017. © 2017Wiley Periodicals, Inc.

摘要

慢性干眼(角结膜干燥症)是一个严重问题,在某些人群中可导致角膜干燥及失明风险。因此,针对此类病症的新型治疗方法可能会降低患者的发病率。本研究旨在通过尸体可行性研究来探究一种针对慢性干眼的潜在治疗方法。在10个尸体侧别上,识别出耳颞神经(ATN)的腮腺分支,并将其与同一神经的颞浅前支(STb)进行吻合。然后将STb向前移位并缝合至泪腺。在所有侧别上均能轻松识别出ATN的腮腺分支。在所有侧别上均能轻松识别并游离出ATN的STb。后一支神经在所有侧别上均有足够长度可移至同侧泪腺。基于我们的尸体研究,将腮腺分泌运动纤维重新路由至ATN的浅支,然后将该分支移至泪腺是一种可行的手术操作。现在有必要开展临床研究以证明该手术方法对慢性干眼患者的有效性。《临床解剖学》30:839 - 843, 2017。© 2017威利期刊公司

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