Assi Sulaf, Gulyamova Nargilya, Kneller Paul, Osselton David
Department of Archaeology, Anthropology and Forensic Science, Bournemouth University, Poole, UK.
Hum Psychopharmacol. 2017 May;32(3). doi: 10.1002/hup.2610. Epub 2017 Jun 20.
The objective of this study is to explore the users' perspectives regarding the effects and toxicity of cathinones.
A systematic search of Internet discussion forums yielded 303 threads relevant to the research objectives. The threads were analysed by conventional content analysis where concepts were developed from codes and themes.
The study identified 3 main themes in relation to cathinone use, effects, and toxicity. The first theme considered the modalities of intake of cathinones in relation to the derivative taken (mainly mephedrone, 3-methylmethcathinone, and methylenedioxypyrovalerone), route of administration (eyeballing, insufflation, smoking, intravenous, oral, rectal, and sublingual), multidrug use, and purity of the cathinone derivative. The second theme characterised the main effects of cathinones, that is, increased energy, euphoria, and empathogenic. Toxic effects were reported regarding the nervous system (anxiety, hallucinations, nervousness, and paranoia), cardiovascular system (angina, myocardial infarction, and tachycardia), skin (discolouration, itching, and allergy), and renal system (difficulty in urination). Drug-drug interactions were also reported including multiple drug use between cathinones, stimulants, depressants, and hallucinogens.
The Internet discussion forums provide useful sources of information regarding the effects and toxicity of cathinones, which can be taken into account when assessing the safety of drugs.
本研究的目的是探讨用户对卡西酮类药物的效果和毒性的看法。
对互联网讨论论坛进行系统搜索，得到303个与研究目标相关的主题帖。通过传统内容分析法对这些主题帖进行分析，从编码和主题中提炼概念。
该研究确定了与卡西酮类药物使用、效果和毒性相关的3个主要主题。第一个主题考虑了卡西酮类药物的摄入方式，涉及所服用的衍生物（主要是甲氧麻黄酮、3-甲基甲卡西酮和亚甲二氧基吡咯戊酮）、给药途径（滴入、吸入、吸烟、静脉注射、口服、直肠给药和舌下给药）、多药联用以及卡西酮衍生物的纯度。第二个主题描述了卡西酮类药物的主要效果，即精力增强、欣快感和情感共鸣。报告了有关神经系统（焦虑、幻觉、紧张和偏执）、心血管系统（心绞痛、心肌梗死和心动过速）、皮肤（变色、瘙痒和过敏）以及泌尿系统（排尿困难）的毒性作用。还报告了药物相互作用，包括卡西酮类药物与兴奋剂、抑制剂和致幻剂之间的多药联用。
互联网讨论论坛提供了有关卡西酮类药物效果和毒性的有用信息来源，在评估药物安全性时可予以考虑。
