血脂异常：他汀类药物相关的肌肉症状——真的都只是心理作用吗？ - Suppr

Dyslipidaemia: Statin-associated muscle symptoms - really all in the mind?

作者信息

Stoekenbroek Robert M, Kastelein John J P

机构信息

Department of Vascular Medicine, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

出版信息

Nat Rev Cardiol. 2017 Aug;14(8):445-446. doi: 10.1038/nrcardio.2017.92. Epub 2017 Jun 15.

DOI:10.1038/nrcardio.2017.92

PMID:28631752

Abstract

摘要

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Dyslipidaemia: Statin-associated muscle symptoms - really all in the mind?血脂异常：他汀类药物相关的肌肉症状——真的都只是心理作用吗？

Nat Rev Cardiol. 2017 Aug;14(8):445-446. doi: 10.1038/nrcardio.2017.92. Epub 2017 Jun 15.

MY APPROACH to Managing Statin-Associated Muscle Symptoms.我处理他汀类药物相关肌肉症状的方法。

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New insights into managing symptoms during statin therapy.他汀类药物治疗期间症状管理的新见解。

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Update on SAMS: Statin-associated muscle symptoms.他汀类药物相关肌肉症状（SAMS）的最新进展

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Statin Intolerance From a Clinician's Perspective.临床医生视角下的他汀不耐受

Angiology. 2016 Mar;67(3):205-7. doi: 10.1177/0003319715587416. Epub 2015 May 27.

Step-by-step diagnosis and management of the nocebo/drucebo effect in statin-associated muscle symptoms patients: a position paper from the International Lipid Expert Panel (ILEP).逐步诊断和管理他汀类药物相关肌肉症状患者的安慰剂/反安慰剂效应：国际脂质专家组（ILEP）的立场文件。

J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1596-1622. doi: 10.1002/jcsm.12960. Epub 2022 Mar 10.

Managing statin myopathy.他汀类药物性肌病的管理

Endocrinol Metab Clin North Am. 2009 Mar;38(1):121-36. doi: 10.1016/j.ecl.2008.11.002.

Statin myopathy: the iceberg or its tip?他汀类药物所致肌病：冰山一角还是全貌？

Muscle Nerve. 2006 Oct;34(4):387-90. doi: 10.1002/mus.20603.

Autoimmune myopathy due to statin treatment in an elderly woman.一名老年女性因他汀类药物治疗导致的自身免疫性肌病。

J Am Geriatr Soc. 2014 May;62(5):991-2. doi: 10.1111/jgs.12789.

Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel.他汀不耐受——统一定义的尝试。国际脂质专家小组立场文件。

Expert Opin Drug Saf. 2015 Jun;14(6):935-55. doi: 10.1517/14740338.2015.1039980. Epub 2015 Apr 24.

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Nocebo Effects on Muscular Performance - An Experimental Study About Clinical Situations.安慰剂效应与肌肉表现——关于临床情况的实验研究

Front Pharmacol. 2019 Mar 11;10:219. doi: 10.3389/fphar.2019.00219. eCollection 2019.

Statin dose reduction with complementary diet therapy: A pilot study of personalized medicine.他汀类药物剂量减少与补充饮食疗法：个性化医学的初步研究。

Mol Metab. 2018 May;11:137-144. doi: 10.1016/j.molmet.2018.02.005. Epub 2018 Feb 20.

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Adverse events associated with unblinded, but not with blinded, statin therapy in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm (ASCOT-LLA): a randomised double-blind placebo-controlled trial and its non-randomised non-blind extension phase.在 Anglo-Scandinavian Cardiac Outcomes Trial-Lipid-Lowering Arm（ASCOT-LLA）中，与未设盲、但与设盲他汀类药物治疗相关的不良事件：一项随机、双盲、安慰剂对照试验及其非随机、非盲扩展阶段。

Lancet. 2017 Jun 24;389(10088):2473-2481. doi: 10.1016/S0140-6736(17)31075-9. Epub 2017 May 2.

The Statin-Associated Muscle Symptom Clinical Index (SAMS-CI): Revision for Clinical Use, Content Validation, and Inter-rater Reliability.他汀类药物相关肌肉症状临床指数（SAMS-CI）：临床应用修订、内容效度及评分者间信度

Cardiovasc Drugs Ther. 2017 Apr;31(2):179-186. doi: 10.1007/s10557-017-6723-4.

Statin Intolerance and Risk of Coronary Heart Events and All-Cause Mortality Following Myocardial Infarction.他汀类药物不耐受与心肌梗死后冠心病事件和全因死亡率的关系。

J Am Coll Cardiol. 2017 Mar 21;69(11):1386-1395. doi: 10.1016/j.jacc.2016.12.036.

Retrospective examination of lipid-lowering treatment patterns in a real-world high-risk cohort in the UK in 2014: comparison with the National Institute for Health and Care Excellence (NICE) 2014 lipid modification guidelines.2014年英国一个真实世界高风险队列中降脂治疗模式的回顾性研究：与英国国家卫生与临床优化研究所（NICE）2014年血脂修饰指南的比较。

BMJ Open. 2017 Feb 17;7(2):e013255. doi: 10.1136/bmjopen-2016-013255.

Interpretation of the evidence for the efficacy and safety of statin therapy.他汀类药物治疗疗效和安全性证据解读。

Lancet. 2016 Nov 19;388(10059):2532-2561. doi: 10.1016/S0140-6736(16)31357-5. Epub 2016 Sep 8.

Efficacy and Tolerability of Evolocumab vs Ezetimibe in Patients With Muscle-Related Statin Intolerance: The GAUSS-3 Randomized Clinical Trial.依洛尤单抗与依折麦布治疗肌肉相关他汀类药物不耐受患者的疗效和耐受性：GAUSS-3 随机临床试验。

JAMA. 2016 Apr 19;315(15):1580-90. doi: 10.1001/jama.2016.3608.

Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial.在他汀类药物不耐受患者中，阿利西尤单抗与依折麦布的疗效和安全性对比，并设他汀类药物再激发组：ODYSSEY ALTERNATIVE随机试验

J Clin Lipidol. 2015 Nov-Dec;9(6):758-769. doi: 10.1016/j.jacl.2015.08.006. Epub 2015 Aug 29.

Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management.他汀类药物相关肌肉症状：对他汀类药物治疗的影响——欧洲动脉粥样硬化学会关于评估、病因及管理的共识专家组声明

Eur Heart J. 2015 May 1;36(17):1012-22. doi: 10.1093/eurheartj/ehv043. Epub 2015 Feb 18.

Understanding Statin Use in America and Gaps in Patient Education (USAGE): an internet-based survey of 10,138 current and former statin users.了解美国的他汀类药物使用情况和患者教育中的差距（USAGE）：一项针对 10138 名现用和曾用他汀类药物患者的基于互联网的调查。

J Clin Lipidol. 2012 May-Jun;6(3):208-15. doi: 10.1016/j.jacl.2012.03.003.

Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients--the PRIMO study.高脂血症患者高剂量他汀类药物治疗的轻至中度肌肉症状——PRIMO研究

Cardiovasc Drugs Ther. 2005 Dec;19(6):403-14. doi: 10.1007/s10557-005-5686-z.

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Dyslipidaemia: Statin-associated muscle symptoms - really all in the mind?

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