Cope Steven, Mohn-Johnsen Samantha
a Department of Occupational Therapy , The College of St. Scholastica , Duluth , MN , USA.
b Department of Physical Therapy , The College of St. Scholastica , Duluth , MN , USA.
Dev Neurorehabil. 2017 Aug;20(6):376-387. doi: 10.1080/17518423.2017.1282053. Epub 2017 Feb 16.
Provide an updated review regarding treatment dosage for children with cerebral palsy (CP) by examining the variables of type, time, frequency, and intensity.
A systematic review was performed with 30 articles meeting the inclusion criteria. Two authors independently extracted data including information about risk of bias. Ten articles were included in the review.
Eight studies manipulated time, two studies manipulated frequency, and three studies manipulated both variables. No studies investigated intensity. Findings suggest that manipulating time and/or frequency may result in better motor function for higher total dosing; however, benefits were not consistent across studies and few showed clinically significant improvements.
This most current evidence regarding the effect of dosage on motor function for children with CP suggests that there is insufficient evidence to support implementing high-dosage therapy. Further research is needed to clarify the relationship between dosage variables on motor function for children with CP.
通过研究类型、时间、频率和强度等变量，提供关于脑瘫（CP）患儿治疗剂量的最新综述。
对30篇符合纳入标准的文章进行系统综述。两位作者独立提取数据，包括偏倚风险信息。该综述纳入了10篇文章。
八项研究操纵了时间，两项研究操纵了频率，三项研究同时操纵了这两个变量。没有研究调查强度。研究结果表明，操纵时间和/或频率可能会因总剂量较高而产生更好的运动功能；然而，各研究结果并不一致，很少有研究显示出具有临床意义的改善。
关于剂量对CP患儿运动功能影响的最新证据表明，没有足够的证据支持实施高剂量治疗。需要进一步研究以阐明CP患儿剂量变量与运动功能之间的关系。
