Liu F T, Katz D H
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1430-4. doi: 10.1073/pnas.76.3.1430.
Administration of stable conjugates prepared by coupling protein antigens such as ovalbumin or antigen E of ragweed extract to the synthetic random copolymer of D-glutamic acid and D-lysine (D-GL) is effective in inducing a state of long-lasting, antigen-specific immunological tolerance in experimental animals. A striking aspect of the tolerance induced by protein-D-GL conjugates is the remarkable selectivity of the tolerance for antibody responses of the IgE class. Protein-D-GL conjugates of either type were capable of inducing such tolerance both in unsensitized and in previously sensitized animals when administered in appropriate doses. Comparable doses of unconjugated proteins were likewise capable of suppressing IgE antibody production, although the duration of suppression in these cases was significantly less than that observed with protein-D-GL conjugates. If such conjugates act in man as they do in experimental animals, they could be of great value as therapeutic agents in selectively diminishing IgE antibody production while sparing antibody production in the IgG class.
将蛋白质抗原（如卵清蛋白或豚草提取物的抗原E）与D-谷氨酸和D-赖氨酸的合成无规共聚物（D-GL）偶联制备的稳定偶联物，在实验动物中能有效诱导持久的、抗原特异性的免疫耐受状态。蛋白质-D-GL偶联物诱导的耐受的一个显著方面是对IgE类抗体反应的耐受具有显著的选择性。当以适当剂量给药时，这两种类型的蛋白质-D-GL偶联物在未致敏和先前致敏的动物中均能诱导这种耐受。相当剂量的未偶联蛋白质同样能够抑制IgE抗体的产生，尽管在这些情况下抑制的持续时间明显短于蛋白质-D-GL偶联物所观察到的。如果这种偶联物在人体中的作用与在实验动物中的作用相同，那么它们作为治疗剂在选择性减少IgE抗体产生同时保留IgG类抗体产生方面可能具有巨大价值。
