• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Failure of lymphocytes to reexpress antigen receptors after brief interaction with a tolerogenic D-amino acid copolymer.淋巴细胞在与致耐受性D-氨基酸共聚物短暂相互作用后未能重新表达抗原受体。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3111-4. doi: 10.1073/pnas.71.8.3111.
2
Induction of B cell tolerance in vitro to 2,4-dinitrophenyl coupled to a copolymer of D-glutamic acid and D-lysine (DNP-D-GL).体外诱导B细胞对与D-谷氨酸和D-赖氨酸共聚物偶联的2,4-二硝基苯基（DNP-D-GL）产生耐受性。
J Exp Med. 1973 Jul 1;138(1):312-7. doi: 10.1084/jem.138.1.312.
3
Immunological tolerance in bone marrow-derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells.骨髓源性淋巴细胞中的免疫耐受性。I. 抗体形成细胞的半抗原特异性前体细胞失活的细胞内机制的证据。
J Exp Med. 1972 Dec 1;136(6):1404-29. doi: 10.1084/jem.136.6.1404.
4
Immunologic tolerance to allergenic protein determinants: properties of tolerance induced in mice treated with conjugates of protein and a synthetic copolymer of D-glutamic acid and D-lysine (D-GL).对变应原性蛋白质决定簇的免疫耐受：用蛋白质与D-谷氨酸和D-赖氨酸的合成共聚物（D-GL）的缀合物处理的小鼠中诱导的耐受特性。
J Immunol. 1979 Dec;123(6):2456-65.
5
Failure to induce tolerance to 2,4-dinitrochlorobenzene contact sensitivity with a 2,4-dinitrophenyl (DNP) conjugate of a copolymer of D-glutamic acid and D-lysine, a specific tolerogen for DNP B cells.
J Immunol. 1974 Mar;112(3):1158-63.
6
Immunological tolerance in bone marrow-derived lymphocytes. II. Effects of allogeneic cell interactions and enzymatic digestion with trypsin or inactivated hapten-specific precursors of antibody-forming cells.骨髓来源淋巴细胞中的免疫耐受性。II. 同种异体细胞相互作用以及用胰蛋白酶或抗体形成细胞的无活性半抗原特异性前体进行酶消化的影响。
J Exp Med. 1974 Jun 1;139(6):1446-63. doi: 10.1084/jem.139.6.1446.
7
Induction of T lymphocyte responses to a small molecular weight antigen. I. Failure to induce tolerance in azobenzenearsonate (ABA)-specific T cells in guinea pigs with an ABA conjugate of A copolymer of D-glutamic acid and D-lysine (D-GL).T淋巴细胞对小分子抗原的应答诱导。I. 用D-谷氨酸和D-赖氨酸的共聚物（D-GL）的偶氮苯砷酸盐（ABA）共轭物在豚鼠中未能诱导ABA特异性T细胞产生耐受性。
J Immunol. 1975 Jul;115(1):272-7.
8
Inuction of immunological tolerance in immunoglobulin E B lymphocytes in rats.大鼠免疫球蛋白E B淋巴细胞免疫耐受的诱导
J Allergy Clin Immunol. 1975 Jun;55(6):403-10. doi: 10.1016/0091-6749(75)90079-2.
9
Induction of immunological tolerance in bone marrow-derived lymphocytes of the IgE antibody class.诱导IgE抗体类骨髓来源淋巴细胞的免疫耐受。
Proc Natl Acad Sci U S A. 1973 Oct;70(10):2776-80. doi: 10.1073/pnas.70.10.2776.
10
Ineffectiveness of lipopolysaccharide for preventing the tolerance induction in bone marrow-derived lymphoid cells with dinitrophenyl-poly-L-(glutamic acid, lysine).
Jpn J Microbiol. 1976 Oct;20(5):425-33. doi: 10.1111/j.1348-0421.1976.tb01008.x.

引用本文的文献

1
Control of B-lymphocyte function. I. Inactivation of mitogenesis by interactions with surface immunoglobulin and Fc-receptor molecules.B淋巴细胞功能的调控。I. 通过与表面免疫球蛋白和Fc受体分子相互作用使有丝分裂原失活。
J Exp Med. 1976 Oct 1;144(4):882-96. doi: 10.1084/jem.144.4.882.
2
Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen.来自对胸腺依赖性抗原产生耐受的动物的脾细胞，可被脂多糖激活，以合成针对该耐受原的抗体。
J Exp Med. 1976 Jun 1;143(6):1429-38. doi: 10.1084/jem.143.6.1429.
3
Immunological tolerance to allergenic protein determinants: a therapeutic approach for selective inhibition of IgE antibody production.对变应原蛋白决定簇的免疫耐受：一种选择性抑制IgE抗体产生的治疗方法。
Proc Natl Acad Sci U S A. 1979 Mar;76(3):1430-4. doi: 10.1073/pnas.76.3.1430.
4
Induction if immunological tolerance to the major antigenic determinant of penicillin: a therapeutic approach to penicillin allergy.诱导对青霉素主要抗原决定簇的免疫耐受：一种治疗青霉素过敏的方法。
Proc Natl Acad Sci U S A. 1976 Jun;73(6):2091-5. doi: 10.1073/pnas.73.6.2091.
5
Antigen-induced aggregation and modulation of receptors on hapten-specific B lymphocytes.抗原诱导的半抗原特异性B淋巴细胞上受体的聚集与调节。
J Exp Med. 1976 Mar 1;143(3):511-28. doi: 10.1084/jem.143.3.511.

本文引用的文献

1
Hapten-specific tolerance. Preferential depression of the high affinity antibody response.半抗原特异性耐受。高亲和力抗体应答的优先抑制。
J Exp Med. 1972 Sep 1;136(3):426-38. doi: 10.1084/jem.136.3.426.
2
Nonantigenicity and immunologic tolerance: the role of the carrier in the induction of tolerance to the hapten.非抗原性与免疫耐受性：载体在诱导对半抗原的耐受性中的作用。
J Exp Med. 1971 Oct 1;134(4):1046-61. doi: 10.1084/jem.134.4.1046.
3
Induction of immunological tolerance by a hapten (DNP) bound to a non-immunogenic protein carrier.通过与非免疫原性蛋白质载体结合的半抗原（二硝基苯酚）诱导免疫耐受。
Nat New Biol. 1971 Apr 7;230(14):180-2. doi: 10.1038/newbio230180a0.
4
Ligand-induced movement of lymphocyte membrane macromolecules. I. Analysis by immunofluorescence and ultrastructural radioautography.配体诱导的淋巴细胞膜大分子运动。I. 免疫荧光和超微结构放射自显影分析。
J Exp Med. 1972 Oct 1;136(4):885-906. doi: 10.1084/jem.136.4.885.
5
Events after the binding of antigen to lymphocytes: removal and regeneration of the antigen receptor.抗原与淋巴细胞结合后的事件：抗原受体的清除与再生
J Exp Med. 1974 May 1;139(5):1110-24. doi: 10.1084/jem.139.5.1110.
6
Hapten-specific tolerance: unresponsiveness in the T cell-depleted population.半抗原特异性耐受：T细胞耗竭群体中的无反应性。
Eur J Immunol. 1973 Jul;3(7):457-60. doi: 10.1002/eji.1830030716.
7
Redistribution and fate of Ig complexes on surface of B lymphocytes: functional implications and mechanisms.B淋巴细胞表面免疫球蛋白复合物的再分布与命运：功能意义及机制
Transplant Rev. 1973;14:184-210. doi: 10.1111/j.1600-065x.1973.tb00107.x.
8
Induction of B cell tolerance in vitro to 2,4-dinitrophenyl coupled to a copolymer of D-glutamic acid and D-lysine (DNP-D-GL).体外诱导B细胞对与D-谷氨酸和D-赖氨酸共聚物偶联的2,4-二硝基苯基（DNP-D-GL）产生耐受性。
J Exp Med. 1973 Jul 1;138(1):312-7. doi: 10.1084/jem.138.1.312.
9
The allogeneic effect in inbred mice. 3. Unique antigenic structural requirements in the expression of the phenomenon on unprimed cell populations in vivo.近交系小鼠中的同种异体效应。3. 体内未致敏细胞群体中该现象表达的独特抗原结构要求。
J Exp Med. 1973 Apr 1;137(4):991-1008. doi: 10.1084/jem.137.4.991.
10
Immunological tolerance in bone marrow-derived lymphocytes. I. Evidence for an intracellular mechanism of inactivation of hapten-specific precursors of antibody-forming cells.骨髓源性淋巴细胞中的免疫耐受性。I. 抗体形成细胞的半抗原特异性前体细胞失活的细胞内机制的证据。
J Exp Med. 1972 Dec 1;136(6):1404-29. doi: 10.1084/jem.136.6.1404.

淋巴细胞在与致耐受性D-氨基酸共聚物短暂相互作用后未能重新表达抗原受体。

Failure of lymphocytes to reexpress antigen receptors after brief interaction with a tolerogenic D-amino acid copolymer.

作者信息

Ault K A, Unanue E R, Katz D H, Benacerraf B

出版信息

Proc Natl Acad Sci U S A. 1974 Aug;71(8):3111-4. doi: 10.1073/pnas.71.8.3111.

DOI:10.1073/pnas.71.8.3111
PMID:4547208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388631/
Abstract

We present data concerning a strongly tolerogenic molecule made of a copolymer of D-amino acids that is not metabolizable poly(D-glutamic acid-D-lysine). The dinitrophenyl conjugate of this molecule induces profound tolerance in dinitrophenyl-specific B lymphocytes both in vivo and in vitro. We show that dinitrophenyl-poly(D-glutamic acid-D-lysine) binds to a population of lymphocytes including those specific for dinitrophenyl, that it persists for long periods on these lymphocytes and is poorly internalized by them, and that these lymphocytes are prevented from binding other dinitrophenyl compounds. Despite prolonged culture, they do not reexpress receptors for dinitrophenyl. This behavior of dinitrophenyl-poly(D-glutamic acid-D-lysine) is contrasted to that of metabolizable antigens. This finding indicates that one mechanism of tolerance induced by nonmetabolizable antigens involves the prolonged loss of B lymphocyte receptor function.

摘要

我们展示了有关一种由不可代谢的聚（D-谷氨酸-D-赖氨酸）组成的D-氨基酸共聚物构成的强耐受性分子的数据。该分子的二硝基苯基缀合物在体内和体外均可诱导二硝基苯基特异性B淋巴细胞产生深度耐受性。我们发现，二硝基苯基-聚（D-谷氨酸-D-赖氨酸）可与包括二硝基苯基特异性淋巴细胞在内的一群淋巴细胞结合，它在这些淋巴细胞上长期存在且很少被其内化，并且这些淋巴细胞被阻止与其他二硝基苯基化合物结合。尽管经过长时间培养，它们仍不会重新表达二硝基苯基受体。二硝基苯基-聚（D-谷氨酸-D-赖氨酸）的这种行为与可代谢抗原的行为形成对比。这一发现表明，不可代谢抗原诱导耐受性的一种机制涉及B淋巴细胞受体功能的长期丧失。