抗半抗原抗体反应中的载体功能。IV. 诱导半抗原特异性耐受或通过“非免疫原性”半抗原-多肽偶联物刺激抗半抗原回忆反应的实验条件。
Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.
作者信息
Katz D H, Davie J M, Paul W E, Benacerraf B
出版信息
J Exp Med. 1971 Jul 1;134(1):201-23. doi: 10.1084/jem.134.1.201.
Abstract
Administration of nonimmunogenic 2,4-dinitrophenyl (DNP) conjugates of copolymers of D or L-glutamic acid and lysine (GL) induces hapten-specific tolerance in nonimmune and DNP-ovalbumin-primed strain 13 guinea pigs. This tolerant state is evidenced by depressed anti-DNP antibody synthesis in response to challenge with DNP-ovalbumin and by a diminished frequency of DNP-specific antigen-binding cells and of anti-DNP antibody-secreting cells. Such a nonimmunogenic compound (DNP-D-GL) will nevertheless elicit a DNP-specific anamnestic antibody response when administered at an appropriate time to DNP-ovalbumin-primed guinea pigs undergoing a graft-versus-host reaction. These experiments are discussed in terms of a two-cell theory of stimulation of antibody responses.
摘要
给D型或L型谷氨酸与赖氨酸的共聚物（GL）的非免疫原性2,4 - 二硝基苯基（DNP）缀合物给药，可在非免疫的和用DNP - 卵清蛋白致敏的13号品系豚鼠中诱导半抗原特异性耐受。这种耐受状态表现为在用DNP - 卵清蛋白攻击后抗DNP抗体合成受到抑制，以及DNP特异性抗原结合细胞和抗DNP抗体分泌细胞的频率降低。然而，当在适当的时候给正在发生移植物抗宿主反应的DNP - 卵清蛋白致敏豚鼠施用这种非免疫原性化合物（DNP - D - GL）时，它会引发DNP特异性的回忆性抗体反应。根据刺激抗体反应的双细胞理论对这些实验进行了讨论。
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Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.抗半抗原抗体反应中的载体功能。IV. 诱导半抗原特异性耐受或通过“非免疫原性”半抗原-多肽偶联物刺激抗半抗原回忆反应的实验条件。
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