血清铜蓝蛋白和帕金森病纹状体多巴胺转运体密度：与 123I-FP-CIT SPECT 的比较。

Serum Ceruloplasmin and Striatal Dopamine Transporter Density in Parkinson Disease: Comparison With 123I-FP-CIT SPECT.

机构信息

From the Departments of *Nuclear Medicine, and †Neurology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam; ‡Department of Neurology, Ewha Womans University School of Medicine, Ewha Womans University Mokdong Hospital, Seoul; §Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul; and ∥Center for Nanomolecular Imaging and Innovative Drug Development, Advanced Institutes of Convergence Technology, Suwon, Republic of Korea.

出版信息

Clin Nucl Med. 2017 Sep;42(9):675-679. doi: 10.1097/RLU.0000000000001734.

DOI:10.1097/RLU.0000000000001734

PMID:28632695

Abstract

PURPOSE

In patients with Parkinson disease (PD), decreased serum ceruloplasmin levels have been observed. This study investigated a correlation between serum ceruloplasmin-along with its related serum markers- and striatal presynaptic dopaminergic denervation measured with I-FP-CIT SPECT.

METHODS

We analyzed a total of 141 de novo patients divided into 2 groups: the PD group (107 patients with PD) and the disease control group (34 patients with vascular pseudoparkinsonism, essential tremor, or drug-induced parkinsonism). Serum ceruloplasmin and related serum markers, such as copper, iron, total iron-binding capacity, and ferritin, were measured. Specific binding ratios of the striatum, caudate nucleus, putamen, and posterior putamen were obtained by I-FP-CIT SPECT.

RESULTS

There was no difference in the serum markers, except for ceruloplasmin, between the 2 groups. Ceruloplasmin level was significantly lower in PD patients with longer symptom duration (>2 years) than in the disease control group (21.4 ± 3.4 vs 24.0 ± 3.8, P = 0.03). Serum ceruloplasmin had a significant correlation with specific binding ratios of the striatum, caudate nucleus, and putamen in a subgroup with longer symptom duration (P = 0.01, P = 0.02, P = 0.02, respectively, for the subgroup with symptom duration >1 year, and P < 0.01, P < 0.01, P = 0.04, respectively, for the subgroup with symptom duration >2 years).

CONCLUSIONS

Decrease in serum ceruloplasmin had a positive correlation with a decrease in dopamine transporter density in PD patients with symptom duration of more than 1 year.

摘要

目的

在帕金森病（PD）患者中，观察到血清铜蓝蛋白水平降低。本研究调查了血清铜蓝蛋白及其相关血清标志物与使用 I-FP-CIT SPECT 测量的纹状体突触前多巴胺能神经纤维丧失之间的相关性。

方法

我们分析了总共 141 例初诊患者，分为 2 组：PD 组（107 例 PD 患者）和疾病对照组（34 例血管性假性帕金森病、特发性震颤或药物诱导性帕金森病患者）。测量了血清铜蓝蛋白和相关血清标志物，如铜、铁、总铁结合能力和铁蛋白。通过 I-FP-CIT SPECT 获得纹状体、尾状核、壳核和后壳核的特异性结合比。

结果

除铜蓝蛋白外，两组之间的血清标志物无差异。PD 患者的症状持续时间（>2 年）较长者的铜蓝蛋白水平明显低于疾病对照组（21.4±3.4 与 24.0±3.8，P=0.03）。血清铜蓝蛋白与较长症状持续时间亚组的纹状体、尾状核和壳核的特异性结合比具有显著相关性（P=0.01、P=0.02、P=0.02，分别为症状持续时间>1 年的亚组，P<0.01、P<0.01、P=0.04，分别为症状持续时间>2 年的亚组）。