Davis Mark M, Tato Cristina M, Furman David
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, USA.
Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, California, USA.
Nat Immunol. 2017 Jun 20;18(7):725-732. doi: 10.1038/ni.3768.
Systems-biology approaches in immunology take various forms, but here we review strategies for measuring a broad swath of immunological functions as a means of discovering previously unknown relationships and phenomena and as a powerful way of understanding the immune system as a whole. This approach has rejuvenated the field of vaccine development and has fostered hope that new ways will be found to combat infectious diseases that have proven refractory to classical approaches. Systems immunology also presents an important new strategy for understanding human immunity directly, taking advantage of the many ways the immune system of humans can be manipulated.
免疫学中的系统生物学方法有多种形式，但在此我们回顾一些策略，这些策略用于测量广泛的免疫功能，以此发现先前未知的关系和现象，并作为从整体上理解免疫系统的有力方式。这种方法使疫苗开发领域焕发生机，并带来了新的希望，即有望找到对抗那些传统方法已证明难以攻克的传染病的新途径。系统免疫学还提供了一种直接理解人类免疫的重要新策略，这得益于人类免疫系统可被操控的多种方式。
